Early Phase 1 PTSD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older
• You speak and understand English fluently
• You have experienced at least one traumatic event in your lifetime
• You have been formally diagnosed with PTSD, confirmed through a specific clinician-led assessment
• You have never previously received a Stellate Ganglion Block (a type of nerve injection in the neck)
• You own a smartphone that you can use throughout the entire study
• You are willing and able to receive 2 injections (either the active treatment or a placebo) 2 weeks apart at the Rush Pain Clinic
• You are willing and able to take part in daily therapy sessions or daily monitoring activities over the course of one week
• You are willing and able to complete questionnaires and assessments at several points throughout the study

Who may not be able to join:

• Your traumatic event happened within the past month
• You are currently having thoughts of harming yourself or others, with a specific plan and intent to do so
• You have psychosis or mania that is currently not being managed
• You have not been on a stable dose of psychiatric medication for at least one month before the study starts, or you plan to change your medication within 3 months of joining
• You have completed a recognised trauma-focused therapy (such as Cognitive Processing Therapy or Prolonged Exposure) in the past 3 months, or you are currently receiving one of these treatments
• You have an intellectual disability or significant difficulty with thinking or understanding that would prevent you from fully taking part in the treatment
• You are currently taking blood-thinning medications or have a condition that affects how your blood clots
• You have had a recent heart attack, glaucoma, a pre-existing nerve problem on the opposite side of your neck, severe emphysema (a serious lung condition), or a heart electrical conduction problem (confirm with trial site)
• You are allergic to any of the medications used in the injections (ropivacaine, lidocaine, or propofol)
• You currently have an active infection
• You have a serious or unstable medical condition that might require hospitalisation within the next year
• You have a vision or hearing problem that would prevent you from fully taking part in study activities
• You are currently involved in legal proceedings related to the traumatic event that the study would be focusing on
• You have a substance dependence problem that, in the lead researcher's judgment, might require you to be hospitalised if you stopped using the substance
• You have significant ongoing life challenges (such as unstable housing or no internet access) that, in the lead researcher's judgment, could affect your ability to participate fully in the study

Important: Always verify eligibility with the trial site directly before applying.