Phase 1 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with an advanced, inoperable, or spreading solid tumor (such as ovarian, pancreatic, bladder, kidney, liver, gastrointestinal, lung, prostate, or breast cancer) confirmed by a lab test, OR you have been diagnosed with multiple myeloma.
• Your cancer has continued to grow or spread despite standard treatments, or standard treatments are no longer working or cannot be tolerated.
• If you have multiple myeloma, you must have already tried at least 3 previous treatments, including specific types known as a proteasome inhibitor, an IMiD, and an anti-CD38 therapy (confirm with trial site).
• You are 18 years of age or older.
• You are generally able to carry out daily activities, with your overall health rated on a standard scale as 0, 1, or 2 (meaning you are fully active to capable of limited self-care).
• You have at least one area of cancer that can be measured or tracked using standard medical imaging or lab criteria.
• Your liver, kidneys, bone marrow, and other organs are working well enough to meet the trial's requirements (confirm specific levels with trial site).
• Your heart is pumping blood adequately, as measured by a standard heart function test.
• If you are a woman who could become pregnant, you must have a negative pregnancy test before starting and agree to use at least one highly effective form of birth control during the study and for 120 days after your last dose.
• If you are a man who could father a child, you must agree to use at least one highly effective form of birth control during the study and for 120 days after your last dose, and you must not donate sperm during this time.

Who may not be able to join:

• You have serious heart problems, such as severe heart failure, a heart attack in the last 6 months, an unstable irregular heartbeat, a personal or family history of a specific heart rhythm condition called long QT syndrome, or signs of reduced blood flow to the heart on a heart tracing (ECG).
• You have chest pain caused by heart disease, or you have previously had a procedure such as a heart stent, balloon procedure, or bypass surgery.
• You are currently taking medications that are known to affect heart rhythm in a way that may be risky (confirm specific medications with trial site).
• You have an active, uncontrolled infection (bacterial, viral, or fungal) that requires treatment.
• You have a known allergy or sensitivity to the study drug or any of its ingredients (confirm with trial site).
• You are currently breastfeeding.
• You have other significant health conditions that the trial team considers a concern (confirm with trial site).
• You have received cancer treatment within the past 28 days, or within a timeframe based on how long your last treatment stays in the body — whichever is shorter.
• You have had a large area of your body treated with radiation within the past 4 weeks, or a smaller area treated within the past 2 weeks.
• You have had major surgery within the past 30 days.
• You are regularly taking a high dose of steroid medication (more than 20 mg per day of prednisone or an equivalent drug).
• You have an active, significant liver disease such as hepatitis B or C, autoimmune hepatitis, or advanced liver scarring (cirrhosis).
• You have had a serious mood disorder such as major depression within the past two years that is not currently well managed with treatment.
• You have an autoimmune condition (where the immune system attacks the body) that is not currently well controlled.
• You have an uncontrolled hormone or metabolism-related condition, such as thyroid problems, diabetes, or blood sugar issues that are not currently well managed.

Important: Always verify eligibility with the trial site directly before applying.