Phase 2 Obesity Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 18 and 65 years of age
• People who have been diagnosed with a specific inherited kidney condition called ADPKD (Autosomal Dominant Polycystic Kidney Disease), confirmed using a standard set of diagnostic criteria
• People with a body mass index (a measure of body weight relative to height) of 27 or above
• People whose kidneys are still filtering at a reasonable level (confirmed by a specific blood test result — confirm with trial site)
• People whose ADPKD has been classified as a certain severity level (Category C, D, or E) based on a kidney ultrasound or MRI scan done within the last 12 months
• People who are not currently taking part in, or planning to join, any formal weight loss program, structured exercise program, or another medical research study
• People who are able to give their informed consent to participate

Who may not be able to join:

• People who have diabetes
• People who are currently taking, or planning to start, a kidney medication called tolvaptan
• People who have been hospitalised or had major surgery within the last 3 months
• People with high blood pressure that is not well controlled (confirm specific numbers with trial site)
• People who are pregnant, breastfeeding, or unwilling to use appropriate contraception during the trial
• People who regularly use prescription or non-prescription medications that may affect weight, appetite, food intake, or energy levels
• People with a history of a clinically diagnosed eating disorder, such as anorexia nervosa, bulimia, or binge eating disorder
• People whose body weight has changed by more than 5% in the past 3 months for any reason, except weight loss after giving birth
• People who are unable to have an MRI scan, including those with severe claustrophobia, certain implants or medical devices, or non-removable body piercings
• People who have had, or currently have, a cancer diagnosis within the past 5 years
• People with a personal or family history of a specific type of thyroid cancer (medullary thyroid carcinoma), thyroid nodules, or a condition called multiple endocrine neoplasia type 2
• People with a prior history of pancreatitis (inflammation of the pancreas)
• People who weigh 450 pounds (approximately 204 kg) or more

Important: Always verify eligibility with the trial site directly before applying.