Multiple Sclerosis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People of any race, male or female, aged 18 or older
• People who are able to give written consent to take part in research procedures
• People who have been diagnosed with Multiple Sclerosis (MS) by their doctor, confirmed by the trial team, and who have had active disease — meaning at least one active (enhancing) lesion seen on a brain scan in the past 6 months
• People who have not previously been treated for MS with ongoing disease-modifying therapies, though short-term treatments for relapses (such as steroids or plasmapheresis) are acceptable
• People whose referring doctor plans to start them on a high-efficacy MS treatment, such as ocrelizumab or natalizumab, or a similar treatment considered equally effective by the trial team
• People whose recent blood test results (taken within the past 3 months) show no significant abnormalities, as determined by the trial team

Who may not be able to join:

• People who have a specific genetic variation affecting a protein called TSPO (a "low binding polymorphism") — this would be identified through testing (confirm with trial site)
• People who have had an allergic reaction to any of the imaging agents used in the trial: [11C]-CS1P1, [11C]-DPA-713, or [18F]-FDG
• People for whom PET, CT, or MRI scans would be unsafe — for example, those with certain implanted electronic devices or who are unable to lie still for extended periods
• People whose kidneys are not functioning well enough to safely receive the contrast dye used in MRI scans (kidney function measured by a test called eGFR, which must be 60 or above)
• People with severe claustrophobia
• People who are currently pregnant or breastfeeding
• People who are currently receiving radiation therapy
• People who require insulin to manage diabetes
• People for whom a lumbar puncture (spinal tap) would not be safe — this includes people taking blood-thinning medications (other than low-dose aspirin 81mg), people with a blood clotting disorder, or people with a mass in the brain
• People with any other condition that the trial team believes could increase risk, make it hard to complete the research procedures, or affect the quality of the data collected — for example, serious kidney or liver disease, or advanced cancer
• People who have taken part in other research studies involving radioactive agents within the past 12 months, where the combined radiation exposure would exceed the allowed yearly limit

Important: Always verify eligibility with the trial site directly before applying.