Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 18 and 75 years old (male or female)
• People who have been newly diagnosed with glioblastoma (a type of brain tumour), confirmed by a scan or tissue test, where at least 80% of the tumour was surgically removed
• People who have completed a combined chemotherapy and radiation treatment (called CCRT) no less than 4 weeks and no more than 6 weeks before joining the study
• People who have been on a stable or decreasing dose of steroid medication for more than 2 weeks
• People with a Karnofsky score of 70 or above — this is a measure doctors use to assess a person's general ability to carry out daily activities (confirm with trial site)
• People with a life expectancy of more than 12 weeks
• People whose blood and organ function results are within acceptable ranges (confirm with trial site for specific requirements)
• People who agree to use adequate contraception during the study and for 6 months after the last dose of the study treatment
• People who are willing and able to sign a consent form before any study procedures begin
• People whose tumour has a specific genetic feature called MGMT unmethylation — this applies only to a particular group within the trial called the Dose Expansion Cohort (confirm with trial site)

Who may not be able to join:

• People who have already received any cancer treatment other than the combined chemotherapy and radiation treatment (CCRT)
• People whose primary tumour is located in the brain stem or spinal cord
• People who have had a severe allergic reaction to any ingredient in the study drug, JK-1201I
• People who have had serious, uncontrolled, or active heart or blood vessel disease in the past 6 months
• People who are unable to swallow tablets or capsules, or who have significant digestive system problems that could affect how the study drug is absorbed
• People who have seizures that are not well controlled
• People who are currently taking certain medications that cannot be stopped at least 2 weeks before starting the study treatment
• People with severe or uncontrolled high blood pressure
• People who still have unresolved side effects from a previous cancer treatment
• Women who are pregnant or breastfeeding
• People who have tested positive for HIV, or who have an active hepatitis B or hepatitis C infection
• People who have taken part in another clinical trial within the 4 weeks before signing the consent form
• People with a history of mental health disorders
• People whom the trial doctor considers unsuitable to participate for any other reason

Important: Always verify eligibility with the trial site directly before applying.