OCD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been formally diagnosed with Obsessive-Compulsive Disorder (OCD) as their main condition, according to standard diagnostic guidelines (DSM-5)
• Adults aged between 18 and 64 years old
• People who have had severe, treatment-resistant OCD for at least five years, where the condition causes significant distress and affects daily life
• People whose OCD symptoms score at least 28 on a standard OCD severity rating scale called the Y-BOCS, indicating severe symptoms
• People for whom at least three different SSRI antidepressant medications have been tried adequately without sufficient benefit
• People for whom the antidepressant medication clomipramine has been tried adequately without sufficient benefit
• People for whom adding at least one antipsychotic medication to the above treatments has also not provided sufficient benefit
• People who have completed an adequate course of a specific type of talking therapy for OCD (called CBT with Exposure and Response Prevention), amounting to at least 25 documented hours with a specialist therapist, without sufficient benefit
• People whose psychiatric medications have remained stable for the month before surgery
• People who have been approved by a specialist multi-disciplinary medical team to undergo a brain surgery procedure called Deep Brain Stimulation (DBS) within two months of enrolling in the trial
• People who are able to give fully informed written consent to participate
• People who have a family member or close support person willing to attend study visits with them if needed

Who may not be able to join:

• People who have ever been diagnosed with a psychotic disorder, such as schizophrenia
• People who have experienced alcohol or substance abuse or dependence within the past six months (excluding nicotine)
• People considered by the study team to be at high risk of suicidal behaviour or impulsivity
• People who are currently pregnant or plan to become pregnant within the next 24 months
• People who require a medical treatment called diathermy (a type of heat-based therapy, sometimes used in physiotherapy or surgery)
• People who have a neurological or other medical condition that the study team considers would make participation in the study procedures unsafe or unsuitable
• People who have another psychiatric condition that, in the study team's opinion, may interfere with their ability to participate in study activities
• People whose primary diagnosis is Hoarding Disorder rather than OCD

Important: Always verify eligibility with the trial site directly before applying.