Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with esophageal squamous cell carcinoma (a specific type of oesophageal cancer), confirmed through a tissue sample test
• People whose cancer is at a locally advanced but potentially operable stage (stage II or III, meaning it has not spread to distant parts of the body)
• People aged between 18 and 75 years old
• People who are generally well enough to carry out daily activities with little or no limitation (as assessed using a standard medical scale called ECOG, scoring 0 or 1)
• People who have had a test done to measure a protein called PD-L1 on their cancer cells, with results available
• People who have been assessed by a chest surgeon as suitable for surgery to remove the cancer
• People whose blood test results show that their bone marrow, liver, and kidneys are functioning adequately (specific values will be checked by the trial site)
• People who are able to understand the trial and are willing to sign a consent form agreeing to take part

Who may not be able to join:

• People whose cancer has spread to distant parts of the body
• People who have had another cancer diagnosis in the past 5 years, except for certain early-stage or skin cancers that have been fully treated (confirm with trial site)
• People who have had an active autoimmune disease requiring ongoing medical treatment in the past 2 years
• People who currently have an active infection that requires treatment
• People with serious uncontrolled health conditions, such as heart failure, unstable chest pain, irregular heartbeat, ongoing infection, or mental health or personal circumstances that may make it difficult to follow the trial requirements
• People who have previously been treated with certain types of immunotherapy drugs (specifically anti-PD-1, anti-PD-L1, or anti-CTLA-4 medications)
• People who are currently pregnant or breastfeeding; women who could become pregnant will need a negative blood pregnancy test within 7 days before being enrolled
• People who are known to have an allergy or sensitivity to the study medications or any of their ingredients

Important: Always verify eligibility with the trial site directly before applying.