Phase 1 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 to 75 years old (inclusive)
• People with a cancer diagnosis that has been confirmed by laboratory tissue testing, where the cancer cannot be surgically removed, has come back, or has spread to other parts of the body
• People who have at least one measurable tumour that can be tracked during the trial (as assessed using standard imaging guidelines called RECIST v1.1)
• People who are generally well enough to carry out everyday activities with little or no limitation (assessed using a standard scale called ECOG, scored 0 or 1)
• People with a life expectancy of more than 12 weeks
• People who are willing and able to use adequate contraception throughout the study
• Women who are not pregnant at the start of the trial, or who are confirmed to be unable to become pregnant
• People who have read, understood, and signed the trial's consent form

Who may not be able to join:

• People who have previously received, or are currently receiving, any cancer treatment that targets a protein called MET, including targeted therapy pills (TKIs), antibodies, or antibody-drug conjugates
• People who have previously received, or are currently receiving, antibody treatments that target a protein called EGFR
• People who have received systemic anti-cancer treatment (including chemotherapy, certain traditional Chinese medicine anti-cancer treatments, or targeted therapy pills) within 2 weeks before the first dose of the trial drug
• People who have received any other experimental anti-cancer drugs, antibodies, or antibody-drug conjugates within 4 weeks before the first dose of the trial drug
• People who have had localised radiotherapy within 2 weeks before the first dose, or large-area radiotherapy (including treatment covering more than 30% of the bone marrow) within 4 weeks before the first dose
• People who have fluid build-up around the lungs or in the abdomen that requires medical treatment, or fluid around the heart
• People who have had major surgery within 4 weeks before the first dose of the trial drug
• People who still have significant side effects (Grade 2 or higher) from previous cancer treatments
• People who have a second active cancer that has not been fully treated
• People who have cancer that has spread to the brain or spinal cord and has not been treated, or is currently active
• People with severe, uncontrolled, or active heart or blood vessel conditions
• People who have had a serious infection within 4 weeks before the first dose of the trial drug

Important: Always verify eligibility with the trial site directly before applying.