Phase 2 Bladder Cancer Trial, Recruiting NCT06637423 Sponsor: Merck Sharp & Dohme LLC Condition: Bladder Cancer
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Phase 2 Bladder Cancer Trial, Recruiting

NCT06637423
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have recurring low-grade bladder cancer (a type that has not spread into the bladder muscle) that has come back after previous treatment
  • People whose bladder tumor was visible during a camera examination of the bladder (cystoscopy) within the 12 weeks before starting the trial
  • People whose bladder cancer is considered intermediate-risk, meaning at least one of the following applies: they have multiple tumors; the cancer has come back more than once within a year; the cancer came back within a year of first being diagnosed; there is a single tumor larger than 3 cm; or previous bladder treatments have not worked
  • People who are reasonably well and able to carry out daily activities, based on a standard health rating scale assessed within 14 days before starting the trial (confirm with trial site)

Who may not be able to join:

  • People who have been newly diagnosed with low-grade bladder cancer for the first time
  • People who have had, or currently have, a more aggressive or advanced form of bladder cancer, including high-grade bladder cancer, cancer that has grown into the bladder muscle, or cancer that has spread to other parts of the body
  • People who have a condition that prevents them from urinating normally, or from holding their urine for one to two hours
  • People who have a history of serious dry eye conditions, serious eyelid gland disease, or serious corneal disease that affects how the eye heals
  • People who have active inflammatory bowel disease (such as Crohn's disease or ulcerative colitis) requiring medications that suppress the immune system, or who have a history of these conditions or chronic diarrhoea
  • People who have serious, uncontrolled heart or blood vessel disease
  • People who have another cancer that is still growing or has needed active treatment within the past three years
  • People who have a history of, or currently have, a non-infectious lung condition involving inflammation of the lung tissue that required steroid treatment

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 23 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Medical Director, Merck Sharp & Dohme LLC

Phone: 1-888-577-8839

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Registry
ClinicalTrials.gov
Start date
20 December 2024
Est. completion
14 March 2029

Where this trial is recruiting

🇨🇦 Canada 🇫🇷 France 🇳🇱 Netherlands 🇪🇸 Spain 🇬🇧 United Kingdom 🇺🇸 United States

Primary endpoints

Number of Participants with Dose Limiting Toxicity (DLT); Number of Participants Experiencing an Adverse Event (AE); Number of Participants Discontinuing Study Treatment due to an Adverse Event (AE)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov