Phase 3 Head and Neck Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have been diagnosed (confirmed by tissue testing) with a type of cancer called squamous cell carcinoma affecting the moist lining of the head and neck area — specifically from the throat (oro/hypopharynx), mouth, upper voice box, the sinus near the cheek, nasal cavity, or from an unknown starting point
- People whose cancer has been assessed at any stage from early to advanced (covering a range of tumour and lymph node classifications)
- People whose treating cancer doctor has determined they are not suitable for radiation therapy given with the goal of curing the cancer
- People who score below 14 on a specific older adult health assessment tool called the Geriatric 8 (confirm with trial site)
- People aged 18 years or older
- People who have had a CT or MRI scan of the head and neck within the 8 weeks before joining the trial
- People who have had a chest CT or chest x-ray (a PET-CT scan may also be accepted if it includes a diagnostic-quality CT)
- People with a physical performance rating of 0 to 3 on a standard scale used in cancer research called the ECOG scale, which ranges from fully active (0) to limited self-care (3)
- People who are capable of having children and have agreed to use a highly effective method of contraception during the treatment period
- People who have had a previous cancer, as long as that prior cancer or its treatment is not expected to interfere with this trial's treatment or results
Who may not be able to join:
- People whose cancer started in the nasopharynx (upper part of the throat behind the nose)
- People who have previously received systemic treatment for cancer, including immunotherapy
- People who have previously had radiation therapy to the head and neck area, with an exception for superficial skin-only radiotherapy that does not overlap with the area to be treated in this trial
- People with a previous head and neck cancer (skin cancers of the head and neck are excluded from this rule)
- People whose tumour is located in an area considered higher risk for serious side effects from the type of radiation used in this trial — including the lower voice box, a certain part of the lower throat, the area behind the voice box, the upper food pipe, or tumours that wrap all the way around the throat, are close to the brain or eyes, or where any single tumour mass is larger than 8 cm
- People whose cancer has spread to more than 2 lymph node regions in the neck (assessed according to specific anatomical rules — confirm details with trial site)
- People whose tumour cannot be clearly seen on CT or MRI scans
- People with clear evidence — either on scans or clinically — that the cancer has spread to distant parts of the body
- People with a connective tissue condition called scleroderma or CREST syndrome
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Ian Poon, Odette Cancer Centre, Sunnybrook Health Sciences, UHN, Toronto, ON Canada
Phone: 613-533-6430
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Overall Survival estimated according to Kaplan-Meier's methodology
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.