Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Written consent has been provided by the patient or their legal representative
• The person is 18 years of age or older, of any gender
• A diagnosis of non-small cell lung cancer (a type of lung cancer) has been confirmed through laboratory testing of tissue or cell samples
• Genetic testing has confirmed the presence of a specific gene change (called an EGFR mutation, either classical or non-classical type)
• A diagnosis of leptomeningeal metastases (cancer that has spread to the membranes surrounding the brain and spinal cord) has been confirmed through symptom assessment, imaging scans, and/or spinal fluid testing, following established specialist diagnostic guidelines
• Both people newly diagnosed with leptomeningeal metastases and those whose cancer has progressed after previous cancer treatments may be considered
• The person has a performance status score of 0 to 3 on the ECOG scale, which broadly means they are able to carry out at least some self-care activities (confirm with trial site)
• Previous radiation therapy or surgery to the brain or spinal cord is permitted
• People experiencing symptoms related to the central nervous system (brain or spinal cord) may be considered, provided those symptoms are not life-threatening
• People who are able to have children must agree to use highly effective contraception during the trial and for 12 months after treatment ends

Who may not be able to join:

• People who currently have a cancer other than non-small cell lung cancer
• People who have had another cancer diagnosis within the past 5 years, with the exception of certain skin, cervical, or breast conditions that have been successfully treated
• People with serious digestive tract conditions that could affect how medication is absorbed, such as peptic ulcers or inflammatory bowel disease
• People with severe or uncontrolled health conditions, including uncontrolled high blood pressure, uncontrolled diabetes, active bleeding, or active infections such as hepatitis B, hepatitis C, or HIV
• People with a history of certain types of lung inflammation (interstitial lung disease), including inflammation caused by medication or previous radiation, or any current signs of this condition
• People with significant heart rhythm problems (such as a prolonged QT interval above 500ms) or heart failure with reduced pumping function
• People who are pregnant or breastfeeding
• People who received a live vaccine within the 4 weeks before starting the trial
• People who are currently participating in, or have participated in, another clinical trial within the past 4 weeks
• People with other serious medical, psychiatric, or laboratory conditions that, in the opinion of the trial investigators, could increase risk or interfere with the trial results, or who may be unable to complete the trial for any reason

Important: Always verify eligibility with the trial site directly before applying.