Obesity Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People of any gender, race, or ethnic background are welcome to participate.
• For the Randomized Study: adults aged 18 up to (but not including) 60 years old. For the Observational Study: adults aged over 60 years old.
• People who have recently been prescribed a weight-loss medication (semaglutide or tirzepatide), have had that prescription approved (by a pharmacy, insurance, or similar), and plan to start and continue that medication for at least 6 months — participants must be recruited before starting the medication.
• People with a BMI over 27.0 who also have at least one weight-related health condition (such as high blood pressure, abnormal cholesterol levels, obstructive sleep apnea, or cardiovascular disease), or a BMI over 30.0 without any of those conditions — there is no upper BMI limit as long as other criteria are met, though the participant must fit within the size limits of the body composition scanning equipment used in the study.
• People who are able to give informed consent before the study begins.
• People who have been cleared by the study doctor as meeting all eligibility requirements.

Who may not be able to join:

• People with Type 2 diabetes.
• People who currently do moderate-to-vigorous exercise for more than 60 minutes per week, or more than one structured cardio or resistance training session per week, over the past 3 months.
• People who have already lost more than 3% of their body weight in the past 3 months.
• People who have had weight-loss (bariatric or metabolic) surgery in the past.
• People who are currently pregnant, were pregnant within the past 6 months, or plan to become pregnant during the study.
• People who have a current medical condition or are receiving treatment that could affect body weight, or that would make it unsafe to participate in the study's tests or exercise programs.
• People with a history of muscle-related conditions that could affect muscle quality or response to exercise (for example, muscular dystrophy, myopathy, or a condition involving severe muscle breakdown).
• People with certain serious heart conditions, including current heart failure, angina, uncontrolled irregular heartbeat, signs of high immediate cardiovascular risk, prior heart attack, history of a weakened heart muscle, prior heart bypass surgery or artery-widening procedures, or conditions requiring ongoing blood-thinning medication (such as a recent or recurring blood clot in a vein).
• People with a resting blood pressure reading above 160/100 mmHg — if taking blood pressure medication, the dose must have been stable for more than 6 months.
• People with an eating disorder that would make weight loss or physical activity unsafe.
• People with a current alcohol or substance use disorder.
• People with an untreated psychological condition, those hospitalised for a psychological condition within the past 12 months, or those who have not been on a stable treatment dose for at least 6 months.
• People who plan to move away from the study site, or have work, personal, or travel commitments that would prevent them from attending required sessions and assessments.

Important: Always verify eligibility with the trial site directly before applying.