Phase 4 Sickle Cell Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are willing and able to sign and date a consent form agreeing to take part
- You are female and between 18 and 50 years old
- You have been diagnosed with sickle cell disease (one of these types: SS, SBeta0, SBeta+, or SC)
- You have had at least 1 pain crisis per month on average over the past 6 months
- You have had between 1 and 10 hospital visits, emergency room visits, or outpatient infusion visits for pain crises in the past year (unless the lead study doctor approves an exception)
- You are willing to stop using any hormonal contraception when you join, and have stopped using it for at least 1 month before joining (or 4 months if you used the injectable contraceptive depot medroxyprogesterone)
- You have regular menstrual cycles (when not using hormonal contraception) that usually last between 21 and 35 days
- You have been on a stable dose of hydroxyurea and any other sickle cell medications for the past 6 months
- You have a phone or device that can send and receive text messages
- You are able to read and understand English
- You are willing to follow all study procedures
Who may not be able to join:
- You have a long-term inflammatory condition such as lupus or inflammatory bowel disease
- You have a history of blood clots in the veins (VTE) or stroke
- You are currently using crizanlizumab, voxelotor, or receiving regular blood transfusions, or you have had a stem cell transplant in the past
- You are currently using any hormonal contraception or have a copper intrauterine device (copper IUD)
- You are currently pregnant or have been pregnant in the last 6 months
- You are currently breastfeeding
- You have polycystic ovary syndrome (PCOS) or have irregular periods
- Your blood pressure was 160/100 or higher at the screening visit
- The study doctor believes that taking part in the trial could put you at risk, affect the study results, or prevent you from completing the full study (confirm with trial site)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Andrea Roe, MD MPH, University of Pennsylvania
Phone: 267-785-8044
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Frequency of acute vaso-occlusive episodes
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.