Phase 1 Transverse Myelitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For Multiple Sclerosis (MS) participants:

• You are between 18 and 60 years old
• Your MS-related disability falls within a certain range, as measured by a standard disability scale called the EDSS (score between 3.0 and 6.5) — confirm with trial site if unsure what your score is
• You have been diagnosed with primary progressive MS, secondary progressive MS, or relapsing MS
• Your disability has been getting worse over the past 12 months in a way that is not linked to relapses

For Neuromyelitis Optica Spectrum Disorder (NMOSD) participants:

• You are between 18 and 65 years old
• Your disability falls within a certain range on the EDSS scale (score between 2.0 and 7.0)
• You have been diagnosed with NMOSD and a specific antibody (AQP4-IgG) has been found in your blood
• You have stopped certain previous medications for a required period before starting this trial (confirm with trial site for details)

For Myasthenia Gravis (MG) participants:

• You are between 18 and 70 years old
• You were diagnosed with generalised myasthenia gravis (gMG) at least 1 year ago
• Your diagnosis has been confirmed by a positive blood test for specific antibodies (AChR or MuSK), plus at least one other confirming test or clinical finding
• Your symptoms significantly affect your daily activities, as measured by a standard MG scale (score of 6 or more)

For Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) participants:

• You are between 18 and 70 years old
• You have been diagnosed with typical CIDP, motor CIDP, or multifocal CIDP (also called Lewis Sumner Syndrome)
• Your disease activity and disability both fall within certain ranges on standard CIDP measurement scales (confirm with trial site for your specific scores)

Who may not be able to join:

• You have had cancer, unless it has been fully in remission for at least 2 years
• You currently have or have previously had a Hepatitis B virus infection
• You have tested positive for HIV
• You have previously had a bone marrow, stem cell, or solid organ transplant
• You have previously received a type of treatment called CAR T-cell therapy or any other gene therapy

Important: Always verify eligibility with the trial site directly before applying. Additional criteria not listed here may also apply.