Head and Neck Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with nasopharyngeal carcinoma (a type of cancer in the back of the nose/throat), confirmed by a tissue or cell sample from the tumor or nearby lymph nodes.
• Your cancer is linked to the Epstein-Barr virus (EBV), shown by a detectable level of EBV in your blood through a lab test.
• Your cancer is at Stage III or Stage IVA (meaning it is locally advanced but has not spread to distant parts of the body), confirmed through a physical exam and specific imaging scans (such as MRI, CT, or PET/CT scans).
• You have already started or are planning to start chemotherapy containing platinum (a common cancer drug) before radiation treatment.
• You are planning to receive a precise type of radiation therapy called IMRT along with platinum-based chemotherapy at the same time.
• Additional immunotherapy treatment after chemoradiation is allowed.
• You are 18 years of age or older.
• You are generally able to carry out daily activities, either fully or with some limitations (confirm with trial site what level of activity is required).
• If you are living with HIV, you are on effective HIV treatment.
• If you have chronic hepatitis B, you are on the appropriate suppressive treatment if your doctor has recommended it.
• If you have had hepatitis C, you are currently being treated for it or have already been successfully treated and cured.
• You have had or currently have another type of cancer, but it is not expected to interfere with this trial's treatments or results (confirm with trial site).
• If you are able to have children, you agree to use reliable birth control during the study and for at least 60 days after your last radiation treatment, and you will notify your doctor right away if you or your partner becomes pregnant.
• You are able to understand the study information and are willing to sign a consent form agreeing to take part.

Who may not be able to join:

• You have previously received chemotherapy specifically for nasopharyngeal carcinoma, other than induction chemotherapy (the initial chemotherapy given before radiation); note that prior chemotherapy for a completely different cancer is allowed.
• You have previously had radiation therapy to the nasopharynx or nearby areas in a way that would overlap with the radiation planned for this trial.
• You have taken part in another clinical trial and received an experimental drug or used an experimental device within the past 4 weeks.
• You have a serious ongoing health condition, such as a major physical or mental illness that could prevent you from completing the treatment or understanding its risks, a recent unstable heart condition or hospitalization for heart or circulation problems in the last 12 months, a recent severe lung condition requiring hospitalization in the last 30 days, or an active serious infection currently requiring intravenous (IV) antibiotics.
• If you are able to become pregnant, you do not have a documented negative pregnancy test on record.
• You have any personal situation or health condition that, in the opinion of the study doctor, would make it unsafe or difficult for you to participate in the trial.

Important: Always verify eligibility with the trial site directly before applying.