Phase 2 Rare Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are able to understand and sign a written consent form agreeing to take part.
• You have been diagnosed (confirmed by a tissue or cell sample) with one of these specific cancer types: Paget's disease of the scrotum with sweat gland cancer, paraganglioma, pheochromocytoma, renal angiomyolipoma, malignant perivascular epithelioid cell tumor (PEComa), rhabdomyosarcoma, or another type of sarcoma that is not rhabdomyosarcoma.
• Your cancer is at an advanced stage (Stage IV), meaning it has spread.
• You are reasonably active and able to care for yourself (confirm with trial site).
• Doctors expect you to live for at least 3 more months.
• Your cancer can be measured on a CT or MRI scan, or it is visible on the skin.
• Your blood counts are at acceptable levels without needing recent blood transfusions (specific blood cell and platelet counts will be checked).
• Your kidneys and liver are functioning well enough, based on blood tests.
• Your blood clotting ability is within an acceptable range, based on blood tests.
• You are willing to use an approved form of contraception from the time you join until at least 120 days after the study ends, and you agree not to donate sperm or store sperm for reproduction during this period.
• You are able and willing to attend all required appointments and follow the study's requirements.

Who may not be able to join:

• You have a serious or uncontrolled illness, such as very high blood pressure, poorly controlled diabetes, significant heart problems (including irregular heartbeat or heart failure), active or uncontrolled serious infections needing ongoing treatment, or a history of active tuberculosis.
• You have active hepatitis (hepatitis B or C virus activity above certain levels in your blood), unless it is being successfully treated and controlled with antiviral medication.
• You have a history of a weakened immune system, including HIV, or any other condition that affects your immune system.
• You have an active autoimmune disease (where your immune system attacks your own body) that has needed treatment in the last two years, with some exceptions such as certain skin conditions, stable thyroid conditions managed with hormone replacement, or similar (confirm with trial site).
• You have had a severe allergic reaction to a monoclonal antibody treatment before, or are known to be allergic to any ingredient in the study drug.
• You have taken part in another clinical trial within the past 4 weeks.
• You have received a live vaccine in the past 30 days, or plan to receive one during the study.
• You have a history of severe allergic reactions.
• You are at risk of bleeding, have a blood clotting problem, or are currently taking clot-dissolving medication.
• You have a history of substance abuse that you cannot stop, or a history of mental illness.
• You have a significant neurological or psychiatric condition, such as dementia, epilepsy, or a history of seizures.
• The trial doctor believes that your overall health condition could put you at risk or prevent you from completing the study safely, or that other personal, family, social, or geographical factors may make participation unsuitable.

Important: Always verify eligibility with the trial site directly before applying.