Phase 2 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with locally advanced or metastatic cervical cancer (Stage IB2–IVB), vaginal cancer (Stage II–IVB), or vulvar cancer (Stage II–IVB), and surgery is not considered your primary treatment option.
• Your cancer can be measured on imaging scans, and you have had a scan (CT or PET-CT) of your chest, abdomen, and pelvis within the past 56 days.
• You are newly diagnosed with your cancer.
• You are 18 years of age or older.
• You are generally well enough to carry out light activity and care for yourself (your doctor will assess this using a standard scale).
• Your blood counts, kidney function, and liver function are within acceptable ranges, based on a blood test taken within the past 28 days.
• If you are HIV-positive, your immune cell count (CD4) is above 200 and you are consistently taking your HIV medications.
• If you have had hepatitis B, the virus is undetectable in your blood while on treatment.
• If you have had hepatitis C, you have been successfully treated and cured, or the virus is currently undetectable in your blood.
• If you have had brain metastases (cancer spread to the brain), they have been treated and follow-up scans show no sign of the cancer growing there.
• If you have or have had another type of cancer, it is unlikely to interfere with this study's treatment or results (confirm with trial site).
• You are able to receive chemoradiation (combined chemotherapy and radiation therapy), and the tumor can be directly accessed for injection as part of the treatment.
• If you are taking steroid medications, your dose has been stable for at least 4 weeks before starting the study treatment.
• You are willing and able to understand the study and give written consent to participate.
• You agree not to donate blood during the study or for 90 days after your last dose of treatment.
• You agree not to breastfeed during the study.
• If you could become pregnant, you have had a negative pregnancy blood test within 14 days before joining the study.

Who may not be able to join:

• You are currently taking part in another clinical trial involving an experimental treatment.
• You have untreated or worsening cancer that has spread to the brain or the lining around the brain.
• You have had a serious allergic reaction to a drug that is chemically or biologically similar to the ones used in this study.
• You have another serious illness that is not well controlled.
• You have a mental health condition or personal circumstances that would make it difficult to follow the study's requirements.
• You are currently pregnant.
• You are currently breastfeeding.

Important: Always verify eligibility with the trial site directly before applying.