Phase 2 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to take part voluntarily, are able to follow the study requirements, and agree to sign a consent form
• You are 18 years of age or older
• You have been diagnosed with kidney cancer (renal cell carcinoma) that has come back or spread, and this was confirmed through a tissue biopsy after surgery to remove the original tumour
• You have already received one type of systemic (whole-body) treatment that either stopped working or caused side effects you could not tolerate, or your cancer came back within 6 months of completing an earlier course of treatment given before or after surgery
• You are able to provide stored tumour tissue samples from your previous surgery (either a tissue block or at least 20 tissue slices) for testing purposes, and the tissue must show a specific pattern of immune cells called TLS (confirm with trial site)
• You have at least one area of cancer that can be measured on a scan, according to standard guidelines
• Your general health and ability to carry out daily activities is rated as good (a score of 0 or 1 on a standard scale used by doctors)
• Your blood counts, liver function, kidney function, blood clotting, and thyroid hormone levels all meet specific minimum standards set by the trial (confirm exact values with trial site)
• If you are a woman who could become pregnant, you must confirm you are not pregnant before joining, and all participants must use reliable contraception throughout treatment and for 4 weeks after treatment ends

Who may not be able to join:

• You have a known allergy to any of the medicines or ingredients used in this trial
• You have received other cancer treatments, local tumour treatments, or taken part in another clinical trial within the 4 weeks before starting this trial (a shorter gap may be allowed in some cases — confirm with trial site)
• You have previously been treated with a specific type of drug that targets BTLA or HVEM (confirm with trial site)
• You have a reason why you cannot take the specific study drugs used in this trial (confirm with trial site)
• You have had or currently have another type of cancer, unless it was cervical cancer, basal cell skin cancer, or squamous cell skin cancer that has been fully cured
• You have an active autoimmune disease (where the immune system attacks the body) that has required treatment in the past 3 months, or a history of a severe autoimmune condition, or need to take steroids or immune-suppressing medicines regularly
• You are known to be HIV positive
• You are pregnant, breastfeeding, or planning to become pregnant during the study
• You have a tendency to bleed (for example, from active stomach ulcers) or are taking blood-thinning medicines such as warfarin or heparin
• You have a history of lung inflammation or scarring (such as interstitial lung disease or radiation damage to the lungs), or there are signs of active lung inflammation on a recent chest scan
• You have other serious health conditions that your doctor feels could put you at risk or affect the study results

Important: Always verify eligibility with the trial site directly before applying.