Phase 2 Sickle Cell Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older at the time of giving consent to join the study.
• Adolescents aged 12 to under 18 may also be eligible, but only if the trial sponsor and an independent safety committee have approved enrollment for that age group.
• People who have been diagnosed with sickle cell disease (SCD), of any type.
• People who have come to the study site with a new pain crisis (called a vaso-occlusive crisis, or VOC) that requires treatment with strong pain medicines given through a drip or injection.

Who may not be able to join:

• People whose pain crisis began more than 72 hours before they received their first injection or drip-based pain medicine.
• People who have had more than 5 pain crises requiring a hospital stay in the past 6 months.
• People who are showing signs of a serious lung complication (called acute chest syndrome).
• People who have new neurological symptoms that may suggest a stroke or mini-stroke.
• People who have any level of sudden kidney damage at the time of the visit.
• People who were discharged from a hospital stay related to a pain crisis or similar event within the 14 days before their current visit.
• People whose blood haemoglobin level is below 6 g/dL (a measure of severe anaemia).
• People whose ferritin level (an iron storage measure) is 2000 ng/mL or above.
• People who are currently taking an approved SCD medication but have not been on a stable, well-tolerated dose of it (confirm with trial site).
• People who are currently taking methadone or buprenorphine.

Important: Always verify eligibility with the trial site directly before applying.