Phase 1 Non-Alcoholic Fatty Liver Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who are willing and able to give informed consent to take part in the trial
- People who are willing and able to follow all trial requirements, in the opinion of the trial investigator
- Women aged 18 years or older
- People with a body mass index (a measure of weight relative to height) between 18 and 45
- People who have reached menopause, defined in one of these ways: women aged 40 or over who have had no periods for at least 1 year, or whose blood test results confirm menopause; women under 40 who have had infrequent or absent periods for at least 4 months and whose blood test results confirm menopause; or women who have had both ovaries surgically removed
- People with low levels of the hormone oestradiol in their blood
- People who have not used systemic (whole-body) hormone replacement therapy (HRT) containing oestrogen in the past 3 months
- People who are willing to allow their GP and any relevant specialist to be told about their participation in the trial
Who may not be able to join:
- People with a known long-term liver disease, except for a condition called MASLD (a type of fatty liver disease)
- People who are using, or have recently used, medications that the investigator believes may significantly affect fat levels or fat processing in the liver
- People whose absent or infrequent periods have a medical cause other than menopause
- People with a history of drinking more than 35 units of alcohol per week, or who have had an alcohol misuse disorder
- People for whom an MRI scan is not medically safe (for example, due to certain metal implants) (confirm with trial site)
- People who have planned surgery or procedures requiring general anaesthesia scheduled during the trial period
- People with any other significant health condition that the investigator believes could put them at risk, affect the trial results, or affect their ability to take part
- People with a life expectancy of less than 6 months
- People who have taken part in another clinical trial involving an investigational product within the past 12 weeks
- People who do not have a sufficient understanding of written or spoken English to take part in the study
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: +441865 857300
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Recruitment into an experimental medicine study investigating the impact of HRT on MASLD
Can't join this trial?
Data last synced from ClinicalTrials.gov: 14 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.