Phase 3 Vitiligo Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 85 years old
• You have been diagnosed with stable, non-segmental vitiligo (a type that does not involve nerve-related patches)
• Your vitiligo affects at least 0.5% of your body surface area on your face and neck
• You have used a prescription cream called tacrolimus 0.1% twice daily for at least 3 months without seeing significant improvement
• You are willing to stop using other vitiligo treatments on your face and neck during the study (some over-the-counter products and camouflage makeup approved by the study team may still be allowed)
• You agree to use effective birth control throughout the study to prevent pregnancy
• You (or your legal representative) are able to understand and sign a consent form agreeing to take part

Who may not be able to join:

• You are not willing to give your consent to participate
• You have a different type of vitiligo or another skin condition that causes loss of skin colour, such as piebaldism or leprosy
• You have previously used strong skin-lightening treatments (other than hydroquinone) for vitiligo or pigmentation
• You have an active skin infection, another skin condition, or a serious health problem that could affect the study or put you at greater risk
• You have a significant medical condition that may make it unsafe to use the study treatment, such as a serious infection, untreated long-term hepatitis, a cancer diagnosis within the last 5 years (with some exceptions), uncontrolled heart or blood vessel disease, blood clots, significant blood disorders, or a history of substance misuse
• You have recently used certain treatments before the study starts — including vitiligo creams (within 1 week), immune-affecting medicines or live vaccines (within 4 weeks), laser or light therapy on your face and neck (within 8 weeks), or biologic medicines (within 12 weeks)
• You have ever used a JAK inhibitor medication before, either as a cream or taken by mouth
• You have a haemoglobin (red blood cell) level below 10 g/dL, significant liver problems, or a confirmed HIV infection
• You are pregnant, breastfeeding, or planning to become pregnant during the study
• You are unlikely or unable to follow the requirements of the study

Important: Always verify eligibility with the trial site directly before applying.