Phase 2 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to take part voluntarily, have been fully informed about the study, and are able to follow all trial procedures.
• Women aged 18 to 65 years at the time of signing the consent form.
• People with a general health and activity level rated as 0 or 1 on a standard medical scale, meaning fully active or able to carry out light work (confirm with trial site).
• People whose cancer cells test positive for a protein called PD-L1, with a score of 1 or higher on a standard test.
• People diagnosed with one of three types of cervical cancer: squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma.
• People whose cervical cancer is at a specific stage (IB1, IB2, IIA1, or IIA2) and whose doctor has determined they would benefit from major surgery and/or additional treatment after surgery.
• People who have already had a radical hysterectomy (removal of the uterus and surrounding tissue) and removal of pelvic lymph nodes, performed using a specific surgical approach (confirm with trial site).
• People whose post-surgery tissue examination found at least two concerning features, such as cancer spread to lymph nodes, cancer at or near the surgical margins, cancer found in blood or lymph vessels, or deep spread into the cervical tissue.
• People whose blood test results meet specific requirements for blood cell counts, liver function, and kidney function, as assessed by the trial site.
• Women who have a negative pregnancy test within 14 days before starting treatment, agree to use effective contraception during treatment and for 6 months after, and are not breastfeeding.
• People who are willing and able to attend all required trial visits and follow-up appointments.

Who may not be able to join:

• People who have tumour remaining after surgery that could not be fully removed.
• People whose cervical cancer has been confirmed as small cell (neuroendocrine) carcinoma or mucinous adenocarcinoma.
• People who have previously had radiotherapy to the pelvic area.
• People who have had another cancer in the past 5 years, unless it was a fully treated skin cancer (basal cell type) or a non-invasive cancer (carcinoma in situ).
• People who have any active or known autoimmune disease (a condition where the immune system attacks the body).
• People who have a history of, or currently have, an inflammatory or autoimmune disease that has required steroid treatment.
• People who have needed systemic treatment with steroids or other immune-suppressing medicines within the 14 days before joining the trial.
• People who have had a blood clot in a vein or artery within the 6 months before enrolling.
• People with heart disease symptoms or heart-related conditions that are not well controlled.

Important: Always verify eligibility with the trial site directly before applying.