Phase 2 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with clear cell kidney cancer, confirmed by a lab test of tissue or cells.
• You have already tried and not responded to no more than 2 targeted therapy drugs (not including a type called mTOR inhibitors) and 1 immunotherapy drug.
• It has been at least 3 weeks (or at least 5 "half-lives" of the drug) since your last cancer treatment, and any side effects from that treatment have settled enough to meet the study's lab requirements.
• You are able to carry out light activity and care for yourself (a standard activity score of 0 or 1 out of 5).
• You are between 18 and 75 years old, and doctors expect you to live for at least 12 more weeks.
• You have at least one tumour that can be measured on a scan, using standard measurement guidelines.
• Your blood, liver, and kidney test results meet certain minimum health levels — including healthy enough red blood cells, platelets, white blood cells, liver enzymes, kidney function, and heart function (confirm with trial site for exact values).
• If you could become pregnant, you must have a negative pregnancy test within 7 days before joining the trial.
• You and your partner must use effective barrier contraception during the treatment and for 4 weeks after it ends.
• You are able to understand the study and sign a consent form before any study procedures begin.

Who may not be able to join:

• You have only ever received a single targeted therapy drug aimed at VEGF/VEGFR or mTOR, with no other treatments.
• You are currently receiving active cancer treatment (such as chemotherapy, immunotherapy, or surgery), unless enough time has passed since your last dose (confirm with trial site, as the original wording appears unclear).
• Your cancer got worse after being treated with an mTOR-targeting therapy, whether used alone or in combination.
• You have significant fluid build-up in your chest or abdomen causing symptoms, or your cancer has spread to the brain or the covering of the spinal cord.
• You have had another type of cancer in the past 5 years (except certain skin cancers or cervical pre-cancer that were successfully treated).
• You have uncontrolled ongoing health problems such as active infections, uncontrolled diabetes, or serious liver disease.
• You have had a heart attack, heart procedure, stroke, mini-stroke, or severe heart failure in the past 12 months.
• You have had a blood clot in a deep vein or in your lungs within the past 6 months.
• You have had major surgery within the past 4 weeks.
• You have a significant mental health condition that would prevent you from understanding the consent form or following the study rules.
• You are living with HIV.
• You have an active autoimmune disease that has required ongoing medical treatment in the past 2 years.
• You are known to be allergic to drugs similar to the one being studied.
• You have difficulty swallowing tablets or have had stomach or bowel surgery that could affect how the drug is absorbed.
• You have serious lung disease, asthma, or COPD with moderate to severe impairment shown on breathing tests.

Important: Always verify eligibility with the trial site directly before applying.