Phase 2 Lung Cancer Trial, Recruiting NCT06731270 Sponsor: Emory University Condition: Lung Cancer
Back to Lung Cancer

Phase 2 Lung Cancer Trial, Recruiting

NCT06731270
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are 18 years of age or older
  • You have been diagnosed with Stage III or IV non-small cell lung cancer (a type of lung cancer) that has spread or is advanced
  • You are currently being treated with one of these specific immunotherapy drugs approved by the FDA: pembrolizumab, atezolizumab, nivolumab, or cemiplimab — and have been on it for at least 12 weeks
  • Your doctor has seen signs that your cancer may be growing or changing on scans, but does not feel you need to switch treatments immediately — at least one area of cancer must appear to be growing
  • You are well enough to carry out daily activities, with only mild limitations at most (confirm with trial site)
  • Your doctor expects you to live for at least 6 months
  • Your blood cell counts and organ function (blood, kidneys, and liver) meet certain minimum levels based on lab tests (confirm with trial site for exact values)
  • You are able to swallow and take pills by mouth
  • You are willing and able to attend all required appointments and follow the study plan for its full duration

Who may not be able to join:

  • You are currently enrolled in another clinical trial that involves treatment
  • You are currently taking blood-thinning medications, such as warfarin, heparin, rivaroxaban (Xarelto), apixaban (Eliquis), dabigatran (Pradaxa), or similar drugs
  • You have received or are planning to receive a drug called bevacizumab within 6 weeks of starting the study
  • Your blood clotting levels are outside the acceptable range based on a lab test (confirm with trial site)
  • You cannot take anti-inflammatory pain medications (NSAIDs) — for example, if you take daily aspirin for heart or stroke prevention, have stomach ulcers, a known bleeding disorder, a known allergy to NSAIDs, advanced kidney disease, uncontrolled high blood pressure, or a known seizure disorder
  • You are a woman who could become pregnant and are unwilling or unable to use two forms of contraception as described in the study
  • You have another serious illness that is not well controlled
  • You have a history of another cancer (some exceptions may apply — confirm with trial site)
  • You have an active immune system disorder, or an active infection such as tuberculosis, hepatitis B, or hepatitis C
  • You have taken immune-suppressing medications within the past 14 days (some exceptions may apply — confirm with trial site)
  • You have received a live vaccine within the past 30 days before starting the study
  • The study doctor feels, for any reason, that the trial would not be appropriate for you

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 23 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Jennifer W Carlisle, Emory University Hospital/Winship Cancer Institute

Phone: 404-778-5087

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Registry
ClinicalTrials.gov
Start date
9 April 2025
Est. completion
1 January 2027

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Clinical benefit rate (CBR)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov