Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 and older who have been newly diagnosed with a type of blood cancer called Ph- B-ALL or T-ALL (specific forms of acute lymphoblastic leukaemia)
• People whose treating doctor considers them unsuitable for a standard intensive chemotherapy approach (sometimes called a "pediatric-inspired regimen"), for reasons such as older age (around 40 or above) or concerns about tolerating that type of treatment
• People whose leukaemia is detectable in the bone marrow or blood through a specialised laboratory test called multi-parameter flow cytometry
• People who are reasonably well and able to carry out basic daily activities (this is measured on a standard medical scale; a lower level of functioning may be accepted if leukaemia is directly causing it)
• People whose liver function test results fall within acceptable ranges as defined by the trial (confirm with trial site for specific values)
• People whose kidneys are working at an adequate level, as measured by a specific calculation (confirm with trial site)
• People who are expected to survive at least 3 months from causes unrelated to their leukaemia
• People who are able to understand the study information and agree to take part
• Women who could become pregnant must use effective non-hormonal contraception during treatment and for 3 months after the last dose; men with partners who could become pregnant must use effective contraception from signing the consent form until at least 3 months after the last dose

Who may not be able to join:

• People who have already received systemic treatment for ALL, beyond very limited amounts of specific medications used to manage urgent symptoms (confirm with trial site for what is permitted)
• People diagnosed with a related but different condition called Burkitt lymphoma or Burkitt leukaemia
• People whose leukaemia is only present outside the bone marrow, or who have known leukaemia involvement in the brain or spinal fluid
• People with a known allergy or intolerance to any of the study drugs
• People with a history of severe pancreatitis (grade 3 or higher) or a long-term condition affecting pancreas function
• People with known active chronic liver disease, such as cirrhosis, non-alcoholic fatty liver disease, or a related condition
• People with other medical or mental health conditions that the treating doctor believes would make participation unsafe
• People who are pregnant or breastfeeding (a pregnancy test may be required for some women before joining)

Important: Always verify eligibility with the trial site directly before applying.