Phase 1 Psoriatic Arthritis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• A parent or legal guardian must provide written consent before any study activities begin, and the child must also give their agreement if old enough to do so under local law.
• Children and teenagers aged 2 years old up to (but not including) 18 years old at the time of screening.
• People who have a confirmed diagnosis of Juvenile Psoriatic Arthritis (JPsA), diagnosed at least 6 months before screening, based on recognised international classification criteria.
• People whose JPsA is currently active, meaning at least 3 joints are swollen, or tender and have limited movement.
• People who have tried at least one anti-inflammatory painkiller (such as ibuprofen or naproxen) for at least 1 month without enough improvement, or who could not tolerate it.
• People who have tried at least one disease-modifying arthritis medication for at least 2 months without enough improvement, or who could not tolerate it.
• People who are taking certain stable-dose medications alongside the trial treatment may still be eligible, including: methotrexate (at a set maximum dose for at least 4 weeks before the study start), low-dose oral steroids (at or below a specified threshold for at least 7 days before the study start), or a single anti-inflammatory painkiller (stable for at least 1 week before the study start).

Who may not be able to join:

• Children who weigh less than 10 kg at the time of screening.
• People who have taken another experimental drug within 4 weeks or 5 half-lives before the study start (whichever is longer).
• People who have had an allergic reaction to the study drug, its ingredients, or to similar types of medications.
• People who have active inflammatory bowel disease or active eye inflammation (uveitis) at the time of screening or the study start.
• People whose joint disease meets the diagnostic criteria for a different category of juvenile idiopathic arthritis (other than JPsA).
• People who are taking medications that are not permitted under the trial rules.
• People who are taking any non-biologic disease-modifying arthritis medication other than methotrexate at the time of screening.
• People who have a medical or psychiatric condition that, in the treating doctor's opinion, would make it difficult to follow the study requirements.

Important: Always verify eligibility with the trial site directly before applying.