Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been newly diagnosed with a specific type of blood cancer called precursor B-cell acute lymphoblastic leukemia (B-ALL) that has a genetic marker known as the Philadelphia chromosome, confirmed by specific laboratory tests
• People who are 18 years of age or older
• People whose overall health and ability to carry out daily activities falls within an acceptable range, as measured by a standard medical scoring system (scores 0–2 on the ECOG scale — confirm with trial site)
• People whose life expectancy is at least 3 months
• People whose organs (such as heart, liver, and kidneys) are functioning well enough to allow participation in this trial
• People who understand the study and are willing to sign a consent form agreeing to take part
• People (and their partners) who are willing to use effective contraception throughout the treatment period and for at least 12 months after the last dose of the study drug — this applies to men and to women who could become pregnant (women who have been through menopause for at least 12 months are considered unable to become pregnant)

Who may not be able to join:

• People whose leukemia is considered to have developed from a more advanced stage of a different blood cancer called chronic myeloid leukemia (CML)
• People whose leukemia has spread to the brain, spinal cord, or areas outside the bone marrow
• People who have already received any systemic treatment for leukemia, such as targeted therapy, chemotherapy, or radiation therapy (some limited pre-treatment may be allowed — confirm with trial site)
• People who have had a heart attack within the past 12 months, or who have serious heart conditions such as uncontrolled high blood pressure, uncontrolled irregular heartbeat, congestive heart failure, or unstable chest pain; or whose heart pumping function is below a certain level on an ultrasound test (less than 50%)
• People who have significant problems with their lungs, liver, or kidneys — including but not limited to severe infections, uncontrolled diabetes, active tuberculosis, asthma, COPD, or certain lung conditions
• People who have had another type of cancer in the past 5 years, with the exception of certain localised thyroid cancers or skin cancers that have not spread
• People whose blood test results show that liver or kidney function is outside acceptable limits (specific lab thresholds apply — confirm with trial site)
• People who are known to have HIV infection
• People who have any other condition that the trial doctor believes would interfere with the safe use of the study treatment
• People who are unable to understand or follow the requirements of the study

Important: Always verify eligibility with the trial site directly before applying.