Phase 3 Lung Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older at the time of joining the trial
• People whose general health and ability to carry out daily activities meets a specific standard (a score of 0 or 1 on a medical scale used to measure this — confirm with trial site)
• People with a life expectancy of at least 3 months
• People diagnosed with non-small cell lung cancer (NSCLC) that has spread to other parts of the body (Stage IV)
• People whose lung cancer has been confirmed through a tissue or cell sample as a specific type (squamous or non-squamous NSCLC)
• People whose tumour shows high levels of a protein called PD-L1 (above 50%), confirmed through an approved laboratory test
• People who have at least one measurable area of cancer outside the brain, as defined by standard imaging guidelines
• People who have not previously received any systemic (whole-body) treatment for their metastatic NSCLC

Who may not be able to join:

• People whose cancer testing shows a type of lung cancer called small cell lung cancer, or people with non-squamous NSCLC whose tumour has not yet been tested for certain specific genetic changes before joining
• People who have already received any treatment targeting their NSCLC after it spread (metastatic stage)
• People currently enrolled in another clinical study that involves an active treatment intervention (being in a non-treatment observational study or a survival follow-up may be acceptable — confirm with trial site)
• People whose cancer has a specific known genetic change for which approved first-line treatments already exist
• People with brain metastases causing symptoms, brain metastases measuring 1.5 cm or larger, those who received radiation to the brain within 7 days before joining, those who may need brain radiation during the first treatment cycle, or those with cancer that has spread to the lining around the brain or spinal cord
• People who have had another cancer in the past (including a previously treated NSCLC), unless treatment aimed at curing that cancer was completed and there has been no sign of it returning for at least 3 years before joining
• People with an active autoimmune condition or active lung disease that requires ongoing systemic (whole-body) medical treatment
• People who already have nerve damage (peripheral neuropathy) rated at Grade 2 or above on a standard medical scale
• People who had a serious infection within the 4 weeks before joining the trial
• People who had major surgery or serious physical trauma within the 4 weeks before joining the trial
• People with a history of non-infectious lung inflammation (pneumonitis) that required steroid treatment, or who currently have a chronic lung scarring condition (interstitial lung disease)

Important: Always verify eligibility with the trial site directly before applying.