Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with colorectal cancer confirmed by a pathology test, and whose cancer is no longer detectable (called "No Evidence of Disease" or NED) after treatment such as surgery, ablation, or radiotherapy.
• People who have maintained NED status for at least 6 months.
• People who have either received no chemotherapy, or have only received chemotherapy after surgery or as a first course of treatment.
• People who, after at least 6 months of NED, have developed a small number of lung spots (5 or fewer), which doctors consider suitable for a targeted destructive treatment.
• People who have never had radiotherapy to the lungs before.
• People who have at least one measurable tumour spot of a minimum size, as defined by standard imaging measurement guidelines (confirm with trial site for exact size details).
• People whose general physical functioning is rated at 2 or below on a standard medical scale, meaning they are able to carry out basic daily activities, even if some help is needed.
• People whose doctors expect them to live for at least 3 months or more.
• People whose blood counts are at an adequate level, specifically a type of white blood cell (neutrophils) count of at least 1.6 x 10⁹/L, without needing medication to boost blood cell production for at least 7 days before testing.
• People whose liver, kidneys, lungs, and heart are functioning well enough to safely receive at least one of the targeted treatments offered in this trial, as assessed by a treating doctor.
• Women who could become pregnant must agree to use a reliable form of contraception from the time of signing consent until 1 year after treatment ends.
• People who have voluntarily agreed to take part and provided written informed consent.

Who may not be able to join:

• People whose colorectal cancer was first diagnosed already at an advanced or widespread (metastatic) stage.
• People who have more than 5 lung spots, or who have cancer that has spread to the liver, bones, or lymph nodes.
• People whose lung spots are not considered suitable for radiotherapy, as determined by the trial doctors.
• People who have previously received a second or later course of systemic (whole-body) cancer treatment.
• People whose liver or kidney function test results are significantly above the normal range (confirm with trial site for exact values).
• People with a CEA tumour marker blood level of 50 ng/mL or higher (CEA is a protein sometimes elevated in colorectal cancer).
• People with serious ongoing health conditions that could interfere with the study, such as uncontrolled diabetes, stomach ulcers, or severe heart or lung disease, as judged by the research team.
• People with a severe or uncontrolled infection.
• People with an active autoimmune disease (a condition where the immune system attacks the body's own tissues).
• People with significant problems affecting the brain or nervous system.
• People who have had major surgery (other than a lymph node biopsy) within the past 30 days.
• Women who are pregnant, breastfeeding, or of childbearing age and not using contraception.
• People who are known to be allergic to any of the treatments used in this trial.
• People who the research team determine are unsuitable for any other reason.

Important: Always verify eligibility with the trial site directly before applying.