Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with Stage IV squamous non-small cell lung cancer, confirmed by a tissue or cell sample test
• People whose cancer has continued to grow or spread (according to standard medical measurements) after receiving both an immunotherapy drug (anti-PD-1 or PD-L1 type) and platinum-based chemotherapy for Stage IV disease
• People living with HIV, provided their HIV is well controlled on antiviral medication
• People who have tested positive for Hepatitis B surface antigen, provided they have been on Hepatitis B antiviral treatment for at least 4 weeks and the virus is undetectable in their blood
• People with a history of Hepatitis C infection, provided the Hepatitis C virus is no longer detectable in their blood

Who may not be able to join:

• People diagnosed with small cell lung cancer, or with a mixed tumour that contains small cell elements
• People with an uncontrolled or serious heart or blood vessel condition
• People with severe lung problems caused by other lung illnesses, such as blood clots in the lungs within the past 3 months, severe asthma, severe chronic obstructive pulmonary disease, restricted lung function, fluid around the lungs, or certain inflammatory conditions affecting the lungs — or people who have had a full lung removed
• People who are still experiencing side effects (other than hair loss) from previous cancer treatments that have not returned to a mild level or to their pre-treatment baseline
• People with a clinically significant eye (cornea) condition
• People who have previously been treated with a chemotherapy drug called docetaxel, either alone or combined with other treatments
• People who have another cancer that is still growing or has needed active treatment within the past 3 years
• People with untreated cancer that has spread to the brain or spinal cord fluid
• People with evidence of cancer spreading to the membranes surrounding the brain and spinal cord
• People with a history of, a current diagnosis of, or clinical or imaging signs suggesting a serious lung inflammation condition called interstitial lung disease (ILD) or pneumonitis (a history of radiation-related lung inflammation that did not require steroids may be an exception — confirm with trial site)
• People with an active autoimmune disease that has needed systemic (whole-body) medical treatment within the past 2 years (note: standard hormone or steroid replacement therapies appear to be permitted — confirm with trial site)
• People with an active infection currently requiring systemic (whole-body) treatment
• People living with HIV who also have a history of Kaposi's sarcoma or Multicentric Castleman's Disease
• People with active inflammatory bowel disease (such as Crohn's disease, ulcerative colitis, or chronic diarrhoea) that requires immune-suppressing medication, or a clear past history of these conditions
• People with a known history of, or currently active, a neurological condition caused by the immune system reacting to cancer (paraneoplastic syndrome)
• People who have previously received a transplant of donor tissue or a solid organ
• People who have not fully recovered from major surgery, or who are still experiencing complications from surgery

Important: Always verify eligibility with the trial site directly before applying.