Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are over 18 years old
• People whose overall health condition is stable and not changing significantly
• People who have muscle stiffness and weakness on one side of the body (arm) caused by a stroke, brain injury, or lack of oxygen to the brain, where that event happened more than 6 months ago
• People whose affected arm shows significant stiffness in the shoulder muscles that pull the arm inward or rotate it inward, at a level measured at 1+ or higher on a standard stiffness scale
• People who have a pain level greater than 40 out of 100 on a standard pain rating scale
• People whose arm stiffness makes it difficult for caregivers to assist with daily care tasks
• People who have the mental capacity to understand the study and make their own decisions about taking part
• People who are on a stable, unchanged medication schedule
• People who are able to take part in a rehabilitation program and attend scheduled assessment sessions throughout the study

Who may not be able to join:

• People where, in the trial doctor's opinion, taking part would put them at an unacceptable health risk
• People who have had a previous procedure or condition that changed the nerve structure in the affected arm
• People who have had any injection into the affected arm (such as nerve-blocking, scarring, or anaesthetic injections) within the last 4 months
• People who are currently receiving an invasive treatment for muscle stiffness, such as a medication pump delivering medication directly to the spinal fluid
• People who are already enrolled in another clinical trial for a drug or device aimed at treating muscle stiffness
• People who are pregnant or breastfeeding
• People who have an allergy or intolerance to local anaesthetic or to botulinum toxin (a medication used to reduce muscle stiffness)
• People who have certain medical conditions that make botulinum toxin unsafe, including Myasthenia Gravis or Eaton-Lambert syndrome, or who are taking certain medications that may interact with botulinum toxin (such as a class of antibiotics called aminoglycosides) (confirm with trial site)
• People who have a skin condition at the area where treatment would be applied that could affect the treatment or its results
• People taking ongoing medications (prescription or non-prescription) that, in the trial doctor's opinion, could affect their safety or the study results
• People who have certain conditions that make a cold-based nerve treatment (cryoneurolysis) unsafe, including: a condition where abnormal proteins in the blood react to cold (cryoglobulinemia), a condition where red blood cells are broken down by cold temperatures (paroxysmal cold hemoglobinuria), a skin reaction to cold (cold urticaria), a condition causing reduced blood flow to fingers and toes in the cold (Raynaud's disease), any form of nerve damage in the limbs (peripheral neuropathy), or open or infected wounds on the affected arm
• People who have a progressive neurological disease, such as ALS (also known as motor neurone disease)
• People who, in the trial doctor's opinion, may not be suitable for other reasons, such as a history of not following medical instructions, substance addiction, or an unrelated injury to the affected arm

Important: Always verify eligibility with the trial site directly before applying.