Phase 1 Melanoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed (confirmed by lab testing of tissue or cells) with one of these cancer types that is advanced, has spread, or cannot be removed by surgery: GIST (gastrointestinal stromal tumour), small cell lung cancer (SCLC), adenoid cystic carcinoma (ACC), uveal melanoma (a type of eye cancer), neuroendocrine tumour (NET), chromophobe renal cell carcinoma (ChRCC), or clear cell renal cell carcinoma (ccRCC)
• People with GIST who have already received at least one course of a drug called imatinib, or people with the other listed cancer types whose cancer has stopped responding to standard treatments, who are not suitable for standard treatments, who cannot tolerate standard treatments, or who have chosen not to receive standard treatments
• People whose general health and ability to carry out daily activities is rated at a good to moderate level (a score of 0 or 1 on a standard medical scale)
• People whose doctor estimates they are expected to live for at least 3 months before starting treatment in this trial
• People aged 18 years or older
• People whose kidney, liver, and bone marrow are functioning at an adequate level, as shown by recent blood test results
• People whose heart is functioning adequately, as confirmed by a heart imaging scan
• People who have waited a sufficient amount of time since their last cancer treatment before joining the trial (the required waiting period varies depending on the type of treatment previously received, ranging from 14 days to 6 weeks)
• People who test negative for pregnancy at the time of screening (where applicable)
• People who are able to use contraception throughout the trial and for 120 days after the last dose, and who agree to refrain from donating sperm during that same period — or people who are confirmed to be post-menopausal or surgically sterile
• People who are willing and able to give written consent and follow all parts of the trial plan

Who may not be able to join:

• People with any cancer other than GIST who have previously received a c-Kit targeted treatment
• People who have brain metastases (cancer that has spread to the brain) that are untreated, causing symptoms, or currently requiring treatment to manage symptoms
• People who have been taking high-dose steroid tablets or other medicines that suppress the immune system within the 14 days before starting the trial (inhaled steroids are generally allowed)
• People who still have significant side effects from previous cancer treatments that have not sufficiently resolved
• People who have had major surgery within 30 days before starting the trial
• People with significant heart problems
• People with significant abnormalities on a heart rhythm (ECG) test
• People with a known active and clinically significant bacterial, fungal, or viral infection
• People with high blood pressure that has not been adequately controlled despite treatment
• People who have had a blood clot in a vein or in the lungs within the 3 months before screening
• People who have an ongoing infection that requires intravenous (drip) antibiotics or other systemic treatment, or who have an active COVID-19 infection
• People with another serious illness that, in the trial doctor's judgement, would significantly increase the risks of taking part
• People who are pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.