Phase 1 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older who have one or more brain tumors and are already planned to have brain surgery to remove or take a sample of the tumor.
• People who also have cancer that has spread to the lining of the brain or spinal cord, as long as they also have a brain tumor that requires surgery or biopsy.
• People who have previously had radiation to the brain or any other cancer treatments — there is no limit on prior treatments for any group in this trial.
• People with a performance score of 60 or above on a standard scale used to measure ability to carry out daily activities (confirm with trial site).
• People with a life expectancy of more than 12 weeks.
• People who have had enough time since their last cancer treatment for any side effects from that treatment to have settled, as assessed by the trial doctor.
• People whose blood test results, taken within 7 days before starting the study treatment, meet all of the following standards:
  • White blood cell levels (specifically infection-fighting cells) are at or above a minimum threshold, without having received a certain type of blood cell booster injection in the week before treatment starts.
  • Platelet counts (cells that help blood clot) are at or above the required level, without needing ongoing transfusions or boosters to stay there, and without having received a platelet transfusion in the week before treatment starts.
  • Haemoglobin (a measure of red blood cells) is at or above the required level, without needing ongoing transfusions or boosters to maintain it, and without having received a red blood cell transfusion in the week before treatment starts.
  • Kidney function is at or above a minimum level, based on a standard calculation.
  • Liver enzyme levels (markers of liver health) are within an acceptable range, with slightly higher allowances for people who have cancer that has spread to the liver.
  • A measure of how well the liver processes waste products is within an acceptable range, with allowances for people who have a known liver condition called Gilbert's syndrome or liver metastases.

Who may not be able to join:

• People with a known allergy or sensitivity to the study drug or any of its ingredients. (Note: people who are allergic to a type of dye used in MRI scans may still be considered, with precautions or alternative imaging at the discretion of the principal investigator.)
• People who have been diagnosed with more than one separate primary cancer within the past 3 years — with the following exceptions:
  • Certain skin cancers that have been fully removed.
  • A very early-stage cervical condition that has been treated.
  • Slow-growing or low-risk blood or immune conditions that the treating doctor considers unlikely to progress during the trial, such as certain types of leukaemia or a condition called MGUS.
  • Any cancer that has been treated with the aim of a full cure.
  • Other solid tumours that have been treated with the aim of a full cure.
  • For people with metastatic breast cancer: a cancer in the other breast.

Important: Always verify eligibility with the trial site directly before applying.