Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 65 years old
• People who have been diagnosed with nasopharyngeal carcinoma (a type of cancer in the back of the nose/throat) confirmed by a tissue or cell sample, at a specific stage of the disease (stage T1-4, N2-3, M0 — meaning it has spread to nearby lymph nodes but not to distant parts of the body)
• People who have not previously had any cancer treatment, such as surgery, radiotherapy, or chemotherapy
• People who have at least one tumour that can be measured on a scan, according to standard measurement guidelines
• People who are generally well enough to carry out daily activities with little or no limitation (this is measured using a standard health scale called ECOG, scored 0 or 1)
• People with an expected survival of at least 3 months
• People who are willing and able to use contraception from the first dose of the trial medication until 24 weeks after the last dose (this applies to men and to women who could become pregnant)
• People whose major organs (such as liver, kidneys, and blood system) are functioning within broadly normal ranges based on standard blood tests
• People whose treating doctor believes the trial treatment is likely to offer a survival benefit

Who may not be able to join:

• People with an active, known, or suspected condition where the immune system attacks the body (autoimmune disease)
• People with high blood pressure that remains above a certain level (systolic above 160 mmHg or diastolic above 90 mmHg) even when taking blood pressure medication
• People with a known inherited tendency to bleed or problems with blood clotting, or anyone who has had significant bleeding symptoms in the 12 weeks before screening, or who has lost more than 50 ml of blood within any 24-hour period
• People with heart symptoms or heart conditions that are not well managed
• People with certain lung conditions, including interstitial lung disease, medication-related lung inflammation, radiation-related lung inflammation requiring steroid treatment, currently active lung infection with symptoms, or severely reduced lung function
• People with active hepatitis B or hepatitis C infection (based on specific virus level thresholds in blood tests)
• People who are allergic to any of the medications used in this trial
• People who are pregnant or breastfeeding
• People who have any other condition or circumstance that the treating doctor believes could interfere with safe participation in the trial (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.