Phase 1 Brain Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older with a brain tumour called glioblastoma that has come back after previous surgery, and who are planned for another surgery to remove tumour tissue
• People whose tumour tests positive for a protein called GPC3, with a significant amount of the tumour cells (more than 25%) showing a moderate-to-strong presence of this protein (as measured by a lab test on tumour tissue)
• People with a general health and functioning score of 60% or higher on a standard medical scale called the Karnofsky Performance Scale, meaning they are able to care for themselves and carry out some normal activities
• People whose neurological symptoms (such as movement, speech, or thinking) have been stable for at least 7 days before joining the treatment part of the trial
• People who have been on a stable or reducing dose of steroid medication (up to a maximum of 0.1 mg/kg of dexamethasone or an equivalent steroid per day) for at least 7 days before surgery and treatment
• People whose kidneys, liver, and blood are functioning adequately based on lab tests — including kidney filtering rate, liver function, blood clotting, white blood cell count, platelet count, haemoglobin level, and blood oxygen level (confirm specific values with trial site)
• People who have recovered from the side effects of any previous chemotherapy or other investigational treatments before joining
• People who are sexually active and are willing to use effective contraception for 3 months after receiving the T-cell treatment
• People (or their legal guardian) who have read, understood, and signed a consent form agreeing to take part, and have been given a copy of that form

Who may not be able to join:

• People who have had allergic reactions to products containing mouse-derived proteins, or who have developed antibodies against mouse proteins (known as HAMA) — this applies to those who have previously been treated with mouse-derived antibodies
• People who have had an organ transplant at any point
• People who are known to be HIV positive
• People who currently have an active bacterial, fungal, or viral infection (active Hepatitis B or Hepatitis C may be considered separately — confirm with trial site)
• People who are pregnant or breastfeeding
• People with an uncontrolled infection
• People where the treating doctor considers participation to not be in their best interest due to other health risk factors

Important: Always verify eligibility with the trial site directly before applying.