Phase 3 Sickle Cell Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with sickle cell disease of any type (such as SS, SC, S/β0, S/β+, or similar)
- You are 2 years old or older
- You are currently in hospital with Acute Chest Syndrome (ACS), which means you have a new abnormal finding on a chest X-ray, ultrasound, or CT scan, along with a fever and/or breathing problems
- You have needed extra oxygen or breathing support (such as a breathing mask, nasal oxygen tube, or ventilator) for less than 48 hours
- If you are a girl or woman who could become pregnant, you have a negative pregnancy test
- You (or your legal guardian) are willing and able to give written consent to take part
- You are covered by social security or health insurance
- If you could become pregnant, you agree to use effective contraception for up to 3 months after receiving the study treatment
Who may not be able to join:
- The study treatment cannot be given within the first 48 hours of needing extra oxygen or breathing support
- You have a known allergy or sensitivity to tocilizumab (the study drug) or any of its ingredients
- You currently have a serious active infection, such as tuberculosis, hepatitis B or C, herpes zoster, or another serious bacterial, viral, or fungal infection
- You have received a live or weakened vaccine in the last 4 weeks
- You have taken immune-suppressing, anti-rejection, or cell-reducing medications, or have been in another drug trial, within the last 3 months
- You have had a severe allergic or life-threatening reaction to certain types of antibody-based medicines in the past
- You have a history of certain bowel conditions, such as diverticulitis, Crohn's disease, or ulcerative colitis, that could increase the risk of bowel complications
- You have been diagnosed with cancer in the last 3 years
- You are currently pregnant or breastfeeding
- In the doctor's opinion, your condition is expected to deteriorate to death very soon
- Your blood counts or certain blood test results are below safe levels (confirm with trial site)
- Your liver function tests are significantly above the normal range (confirm with trial site)
- Your kidneys are not filtering blood well enough (confirm with trial site)
- You are currently taking part in another clinical drug trial
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Slimane ALLALI, MD, PhD, Department of General Pediatrics and Sickle Cell Center, Necker-Enfants malades Hospital, Paris, France
Phone: 01 44 49 48 96
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Time to successful weaning from both supplemental oxygen and any respiratory support
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.