Phase 3 study
Recruiting Phase 3
This trial at a glance
Where this trial is running
| Site | City | State or country | Status at this site |
|---|---|---|---|
| Canberra Hospital | Canberra | ACT | Not yet recruiting |
| Royal Prince Alfred Hospital | Camperdown | NSW | Not yet recruiting |
| St. Vincent's Health Sydney | Darlinghurst | NSW | Not yet recruiting |
| Dubbo Health Service | Dubbo | NSW | Not yet recruiting |
| Nepean Hospital | Kingswood | NSW | Recruiting |
| St George Hospital | Kogarah | NSW | Recruiting |
| Liverpool Hospital | Liverpool | NSW | Not yet recruiting |
| The George Institute | Randwick | NSW | Not yet recruiting |
| Royal North Shore Hospital | Sydney | NSW | Recruiting |
| Westmead Hospital | Westmead | NSW | Not yet recruiting |
| Royal Darwin Hospital | Tiwi | NT | Not yet recruiting |
| Townsville University Hospital | Douglas | QLD | Not yet recruiting |
| Gold Coast University Hospital | Gold Coast | QLD | Not yet recruiting |
| Royal Brisbane and Women's Hospital | Herston | QLD | Recruiting |
| Princess Alexandra Hospital | Woolloongabba | QLD | Recruiting |
| Royal Adelaide Hospital | Adelaide | SA | Not yet recruiting |
| Royal Hobart Hospital | Hobart | TAS | Not yet recruiting |
| Bendigo Health | Bendigo | VIC | Not yet recruiting |
| Eastern Health Box Hill | Box Hill | VIC | Not yet recruiting |
| St Vincent's Hospital Melbourne | Fitzroy | VIC | Not yet recruiting |
| Footscray Hospital Western Health | Footscray | VIC | Not yet recruiting |
| Austin Health | Heidelberg | VIC | Not yet recruiting |
| The Alfred Hospital | Melbourne | VIC | Not yet recruiting |
| Sunshine Hospital - Western Health | Saint Albans | VIC | Not yet recruiting |
| Sir Charles Gairdner Hospital | Nedlands | WA | Not yet recruiting |
| Royal Perth Hospital | Perth | WA | Not yet recruiting |
| Fiona Stanley Hospital | Perth | WA | Not yet recruiting |
voxsanity.com.au · trial sites from public registries · registry record synced 11 October 2026 · not medical advice
Who can join
The official eligibility criteria
Registry text, reproduced exactly. These are the words the trial's sponsor published on ClinicalTrials.gov. They have not been edited, shortened or rewritten, and they are written for researchers rather than for patients.
Inclusion Criteria:
1. ≥ 18 years of age
2. Receiving invasive mechanical ventilation
3. The requirement for mechanical ventilation is because of an acute brain injury due to intracranial haemorrhage, ischaemic stroke, cerebral venous sinus thrombosis, subarachnoid haemorrhage, suspected hypoxic ischaemic encephalopathy post cardiac arrest, or traumatic brain injury.
4. Admitted to an ICU or is anticipated to be admitted to an ICU
Exclusion Criteria:
1. Endotracheal intubation was more than 12 hours ago
2. Hospital admission was more than 72 hours ago
3. Anticipated inability to deliver trial intervention within 90 minutes of randomisation
4. Documented use of antibiotic therapy in the week prior to hospitalisation
5. Currently receiving antibiotic therapy, or intention to prescribe antibiotic therapy, excluding cephazolin for peri-operative prophylaxis
6. Any contraindication to receiving ceftriaxone
7. Known or suspected pregnancy
8. Death within 90 days is deemed inevitable due to the current illness or intercurrent medical conditions
9. Previously enrolled in the PREVENT-NEURO trial.
Dates on the record
Results, publications and the official record
- No results are posted on the official record yet.
- No publications are listed on the official record yet.
- Official record and contacts on ClinicalTrials.gov – contact details for each site are kept there, and are not copied onto this page.
Sources and dates
- ClinicalTrials.gov – the record this page reformats
- ClinicalTrials.gov processing date: 28 August 2026.
- This page last checked by Voxsanity: 11 October 2026.
Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.
Not medical advice.
Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.
Letter for your doctor
A one-page summary of this trial to print or email to your GP. It carries the registry's own record of the trial and its eligibility criteria, and nothing Voxsanity has written about whether it suits you.