Phase 2 Uveitis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with intestinal Behçet's syndrome (a condition causing inflammation and ulcers in the gut) based on recognized international diagnostic criteria, confirmed by a camera examination of your bowel.
• Your symptoms are currently active and scored at a certain level of severity based on standard assessment tools (confirm with trial site).
• A bowel camera examination within the last 60 days has shown active ulcers in your intestine.
• You have already tried medium-to-high dose steroid tablets for over 1 month, or immune-suppressing medications for over 3 months, or biologic medicines for over 2 months, and your doctor considers these treatments to have failed or been poorly tolerated.
• Your current steroid dose is relatively low and has been stable for at least 2 weeks, and/or your immune-suppressing medication dose has been stable for at least 4 weeks.
• You understand what the study involves, are willing to take part, and are able to sign a consent form.

Who may not be able to join:

• You have been diagnosed with a different bowel condition such as Crohn's disease, ulcerative colitis, or lymphoma.
• You have serious active organ damage related to Behçet's syndrome — such as aneurysms (dangerous bulges in blood vessels), eye inflammation, or significant involvement of the brain or nervous system — that needs stronger immune-suppressing treatment right away.
• Your liver, kidney, or blood count results are significantly abnormal based on specific laboratory thresholds (confirm with trial site).
• You have an active infection such as active tuberculosis, active hepatitis B or C, syphilis, HIV, a long-term Epstein-Barr virus infection, an ongoing serious bacterial or viral infection, or a history of severe shingles.
• You have latent (inactive) tuberculosis and have not yet completed at least 3 weeks of preventative tuberculosis treatment before joining.
• You have a condition where your immune system does not work properly from birth (primary immunodeficiency).
• You have a history of cancer, or bowel tissue samples have shown early signs of cancer or abnormal cell changes.
• Your Behçet's syndrome never responded at all to a biologic medicine called infliximab (though people who responded but later stopped responding, or who could not tolerate it, may still be eligible).
• You have recently been treated with certain biologic or targeted medicines within specific timeframes depending on the medication — including infliximab, etanercept, tofacitinib, and several others (confirm with trial site for exact timeframes).
• You have previously used the medications baricitinib or adalimumab (ADA).
• You have complications of intestinal Behçet's syndrome such as a narrowed bowel causing symptoms, short bowel syndrome, a tunnel-like tract (fistula) in the bowel, or a suspected abscess in the abdomen; or you have had bowel surgery or other abdominal surgery within the last 6 months; or you have a functioning stoma or ostomy bag.
• You need to be fed through a drip or intravenous line because your illness is too severe to absorb nutrition normally.
• You are pregnant, breastfeeding, or planning to become pregnant in the near future.
• You are unable or unwilling to attend regular check-up visits as required by the study.
• You have a history of serious blood clot events or ongoing significant heart or blood vessel problems.

Important: Always verify eligibility with the trial site directly before applying.