Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to take part and sign a consent form in person.
• People aged 18 to 65 years old, who are male or female and not pregnant.
• People who have been diagnosed with a specific type of nasopharyngeal cancer (a cancer at the back of the nose/throat), confirmed by laboratory testing, classified as WHO type II or III (non-keratinising type).
• People who have not yet received any cancer treatment and have no history of other cancers.
• People whose cancer is classified as Stage IVa according to a specific international staging system (8th edition AJCC/UICC), meaning the cancer has spread to certain lymph nodes but not to distant parts of the body.
• People who are generally well enough to carry out light activity and have no serious problems with the heart, lungs, liver, or kidneys (ECOG score of 0 or 1).
• People whose blood test results meet minimum levels for red blood cells, white blood cells, and platelets (confirm with trial site for exact values).
• People whose liver function tests are within acceptable ranges, specifically certain enzyme levels and bilirubin below set thresholds.
• People whose kidney function is within an acceptable range, based on a blood test called serum creatinine.

Who may not be able to join:

• People whose nasopharyngeal cancer has come back after treatment or has spread to distant parts of the body.
• People whose cancer is of a different type called keratinising squamous cell carcinoma (WHO type I).
• People who have received steroid medications (such as cortisone-type drugs) either throughout the body or to a specific area within the 4 weeks before joining the trial.
• People who have taken part in another drug clinical trial within the 3 months before starting treatment.
• People who have previously had an organ transplant or a stem cell transplant from another person.
• People who have certain lung conditions, including a scarring lung disease, drug-related lung inflammation, a condition called bronchiolitis obliterans, radiation-related lung problems requiring treatment, active lung infection, or other moderate to severe lung diseases that significantly affect breathing.
• People who have a condition that requires long-term use of medications that suppress the immune system.
• People who have previously been treated with certain types of immunotherapy drugs (checkpoint inhibitors, including anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 antibodies) and whose cancer was found to be getting worse while on that treatment.
• People who have an active autoimmune disease (where the immune system attacks the body) or a history of one — this includes conditions such as certain lung, eye, gut, liver, pituitary, kidney, or thyroid diseases; people with vitiligo (a skin pigmentation condition) or those whose childhood asthma fully resolved without ongoing treatment as adults may still be eligible, but people with asthma currently requiring medication generally may not be (confirm with trial site).
• People who are HIV-positive, or who test positive for hepatitis B with a measurable level of the virus in their blood, or who test positive for both hepatitis C antibodies and active hepatitis C virus.
• People who have received any vaccination against infections (such as flu or chickenpox vaccines) within the 4 weeks before joining the trial.
• Women of childbearing age who test positive on a pregnancy test, or women who are breastfeeding.
• People who would be unable to attend regular follow-up appointments due to personal, social, family, or geographic reasons.

Important: Always verify eligibility with the trial site directly before applying.