Multiple Sclerosis Trial, Recruiting NCT06864936 Sponsor: University of Maryland, Baltimore Condition: Multiple Sclerosis
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Multiple Sclerosis Trial, Recruiting

NCT06864936
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

For the Ublituximab (treatment) group:

  • You are between 18 and 65 years old
  • You have been diagnosed with relapsing MS (including relapsing-remitting MS or active secondary progressive MS) based on recognised diagnostic guidelines
  • Your doctor has recently referred you to start a medication called ublituximab for your MS

For the Comparison group:

  • You are between 18 and 65 years old
  • You have been diagnosed with relapsing-remitting MS based on recognised diagnostic guidelines
  • You are currently on a steady, unchanged MS medication and do not plan to switch treatments within the next year

Who may not be able to join:

For the Ublituximab group:

  • You have a known eye condition (such as diabetic eye disease, macular degeneration, or glaucoma) that could interfere with the study's eye tests
  • You have received certain MS medications that reduce B-cells (such as rituximab, ocrelizumab, ofatumumab, or ublituximab) within the past 12 months
  • You have had a serious or life-threatening reaction to ublituximab or a similar type of medication in the past
  • You have an ongoing or serious infection, such as active hepatitis B, tuberculosis, or HIV, that would make this type of treatment unsafe
  • You have received a live or weakened-live vaccine within 4 weeks before your first dose of ublituximab

For the Comparison group:

  • You have a known eye condition (such as diabetic eye disease, macular degeneration, or glaucoma) that could interfere with the study's eye tests
  • You have taken certain MS medications that reduce B-cells (such as rituximab, ocrelizumab, ofatumumab, or ublituximab) in the past 12 months, or you plan to start one within the next year

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 22 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Daniel Harrison, MD, University of Maryland, Baltimore

Phone: 410-328-1885

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
1 May 2026
Est. completion
30 December 2027

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Evaluation of the effect of ublituximab on macular hyperreflective foci (HRF) in MS.; Evaluation of the effect of ublituximab on inner limiting membrane (ILM) macrophage-like cells (MLC).

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 22 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov