Phase 2 PTSD Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are United States Military Veterans
• People who have completed at least a high school education or the equivalent (such as a GED)
• People who have a current diagnosis of Post-Traumatic Stress Disorder (PTSD) according to standard diagnostic criteria (DSM-5)
• People whose PTSD symptoms score at or above a certain level on a standard clinical assessment at the start of the trial (confirm with trial site)
• People who are taking SSRI antidepressants, provided the dose has been stable for at least 3 months
• People currently attending talk therapy, provided the type and how often they attend has been stable for at least 2 months before screening and is expected to stay the same throughout the trial
• People who are found to be in generally good physical health based on an interview, medical questionnaire, physical examination, heart tracing (ECG), and routine blood and urine tests
• People who have not used hallucinogenic substances in the past 3 months and have no history of regular or frequent hallucinogen use

Who may not be able to join:

• People who are pregnant, breastfeeding, or are capable of becoming pregnant and are sexually active without using a highly effective form of contraception
• People whose partner is capable of becoming pregnant and who are sexually active without using a highly effective form of contraception
• People with certain heart or blood vessel conditions, such as coronary artery disease, stroke, chest pain (angina), uncontrolled high blood pressure, certain abnormal heart rhythms, a prolonged interval on a heart tracing (ECG), an artificial heart valve, or a mini-stroke (TIA) in the past year
• People whose blood pressure or resting heart rate is above certain levels at screening (confirm with trial site)
• People with epilepsy or a history of seizures
• People with insulin-dependent diabetes, or people taking oral diabetes medication who have experienced symptoms of low blood sugar
• People with a current or past diagnosis of schizophrenia, other psychotic disorders (with some exceptions — confirm with trial site), or Bipolar I or II Disorder
• People who have had a moderate or severe alcohol, tobacco, caffeine, or other substance use disorder in the past six months — note that regular smokers would need to agree to use a nicotine patch on dosing days, as smoking would not be permitted during those sessions
• People who have a parent, sibling, or child with schizophrenia or a related psychotic disorder
• People assessed by a clinician as being at immediate risk of suicide
• People whose psychiatric condition makes it difficult to build a trusting therapeutic relationship, such as those with long-term patterns of unstable relationships, significant stress-related paranoia, or identity disturbances
• People with a history of a medically serious suicide attempt
• People currently taking MAOI antidepressant medications

Important: Always verify eligibility with the trial site directly before applying.