Phase 2 Epilepsy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with focal onset seizures (seizures that start in one part of the brain) or a type of generalized seizure called idiopathic generalized tonic-clonic seizures (full-body convulsive seizures with no known structural cause).
• You have had a brain scan (CT or MRI) in the past that ruled out a worsening or progressive cause for your epilepsy.
• You are currently taking between 1 and 3 approved anti-seizure medications at doses that have been stable for some time.
• You (or your caregiver) report having at least 2 countable focal onset seizures per month, or at least 1 countable generalized tonic-clonic seizure per month, in the 3 months before the screening period.

Who may not be able to join:

• You have had seizures in the past 12 months that are psychological or non-epileptic in origin, seizures that only occur in uncountable clusters, or a severe convulsive episode requiring hospitalization and a breathing tube in the past 12 months.
• You are planning to have brain surgery for epilepsy during the trial.
• You have had brain surgery for seizures within the past year, or radiation-based brain treatment within the past 2 years.
• You have schizophrenia, obsessive-compulsive disorder, or another serious mental health condition.
• You have had an active plan or intent to end your life in the past 6 months, a suicide attempt in the past 2 years, or more than one suicide attempt at any point in your life.
• You have been diagnosed with cancer or certain blood/lymph system disorders within the past 5 years.
• You have a history of heart disease, heart rhythm problems, or structural abnormalities of the heart.
• You are currently pregnant, breastfeeding, have a positive pregnancy test at screening, or plan to become pregnant during the trial or within 14 days of taking the last dose of the study drug.
• You have taken part in another clinical drug or device trial within the past 30 days (or longer, depending on the drug), or have ever received gene therapy.
• You have taken a seizure medication called vigabatrin in the last 5 years, unless your vision has been checked and found to be stable on two occasions in the year after stopping it.
• You have taken or are taking a seizure medication called felbamate, unless you meet specific requirements about how long you have been on it and how recently the dose was changed (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.