Phase 2 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between 18 and 45 years of age
• People who have been diagnosed with a specific type of uterine cancer called endometrioid carcinoma (low-grade, G1 or G2) confirmed by a tissue sample taken through biopsy, scraping of the uterine lining, or a camera procedure inside the uterus, and confirmed by at least two senior doctors
• People whose cancer has been identified as a specific molecular subtype called MMRd (mismatch repair deficient), classified according to World Health Organization guidelines
• People whose scans (such as MRI, CT, or PET/CT) show the cancer is confined to the inner lining of the uterus or only slightly into the uterine wall, with no signs of spread deeper into the wall, the cervix, or beyond the uterus — matching stage IA1 or IA2 under the 2023 FIGO staging system
• People who wish to preserve their fertility, or who wish to keep their uterus even if they do not have plans for pregnancy
• People who are able to attend scheduled follow-up appointments at the trial hospital

Who may not be able to join:

• People with high-grade (G3) endometrioid carcinoma, or other types of uterine cancer such as serous carcinoma, clear cell carcinoma, carcinosarcoma, undifferentiated carcinoma, dedifferentiated carcinoma, neuroendocrine carcinoma, or non-epithelial uterine cancers such as adenosarcoma or stromal sarcoma
• People whose scans suggest the cancer has grown deeply into the uterine wall, into the cervix, or may have spread outside the uterus
• People with a history of a major organ transplant
• People with uncontrolled medical conditions or active infections
• People currently experiencing serious acute conditions such as stroke or heart attack
• People with another cancer of the reproductive system (an exception may apply for people with Lynch syndrome who also have ovarian cancer — confirm with trial site)
• People whose treatment plan requires removal of the uterus or another approach other than conservative medication
• People who are pregnant
• People who have received treatment with high-dose progesterone or oral contraceptives for more than one month in the past three months, for a condition called endometrial hyperplasia
• People who smoke more than 15 cigarettes per day
• People for whom the use of immunosuppressant medications or progesterone is medically inadvisable

Important: Always verify eligibility with the trial site directly before applying.