Phase 2 Thyroid Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You (or your legal representative) are willing and able to give written consent to take part.
• You are at least 21 years old at the time of signing the consent form.
• You have been officially diagnosed (confirmed by lab testing of tissue or cells) with advanced or inoperable salivary gland cancer or thyroid cancer that cannot be treated with local treatments.
• Your cancer can be measured using standard imaging scans (based on a system called RECIST 1.1).
• If you have salivary gland cancer that has spread or come back and cannot be operated on, your cancer must have been growing in the past 6 months, and you must have tried at least one previous cancer drug treatment — unless that treatment was not suitable for you or there is no standard treatment for your specific type.
• If you have a type of thyroid cancer that no longer responds to radioactive iodine treatment, your cancer must have been growing in the past 13 months, and you must have tried at least one previous targeted drug treatment (called a TKI) — unless it was not suitable for you; if your cancer has certain specific genetic changes (RET or NTRK), you must have tried at least two TKI treatments, unless they were not suitable or you chose not to have a second one.
• You are generally well enough to carry out light daily activities (rated 0 or 1 on a standard health scale used in cancer trials).
• Your liver, kidneys, and other organs are working well enough, confirmed by blood tests taken within 10 days before starting treatment.
• You are willing to provide blood samples and tumour tissue (either a new biopsy if possible, or stored tissue) for research purposes.

Who may not be able to join:

• You have cancer that has spread to the brain or the lining around the brain that has not yet been treated.
• You have taken part in another clinical trial or used an experimental treatment or device within the past 4 weeks.
• You have had radiotherapy within the past 2 weeks, or you have not fully recovered from radiation side effects, or you still need steroid medicines because of radiation.
• You have another separate cancer that is still growing or that has needed active treatment within the past 3 years.
• You have had a known serious allergic reaction to the drug used in this trial (Sacituzumab govitecan).
• You currently have an active infection that requires treatment with medicines, including tuberculosis (TB).
• You have any condition, ongoing treatment, or abnormal test result that the trial doctor believes could interfere with the trial results or would make participating unsafe for you (confirm with trial site).
• You have a known mental health condition or substance use problem that would make it difficult to follow the trial requirements.
• You have had any of the following heart or blood vessel events recently:
  • Chest pain from a heart problem in the past 4 weeks
  • A blood clot in the lungs with symptoms in the past 4 weeks
  • A heart attack in the past 6 months
  • Serious heart failure (rated Class III or IV) in the past 6 months
  • A significant irregular heartbeat (Grade 2 or higher) in the past 6 months
  • A stroke in the past 6 months
• You are currently pregnant, breastfeeding, or planning to become pregnant or father a child during the trial period.
• You are a woman who could become pregnant and your pregnancy test (taken within 72 hours before your first dose) is positive.
• You are not willing to use effective contraception during the trial and for at least 6 months after your last dose (for women), or at least 3 months after your last dose and refrain from donating sperm (for men).
• You have received a live vaccine (such as yellow fever, MMR, nasal flu spray, chickenpox, or shingles vaccine) within the past 4 weeks.

Important: Always verify eligibility with the trial site directly before applying.