Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old (any sex).
• You have been diagnosed with squamous cell carcinoma of the head and neck that has been confirmed by a tissue biopsy, and the cancer has either come back after surgery, spread to other parts of the body, or cannot be removed with surgery — and it can be measured on a scan.
• You have already received at least one round of a type of immunotherapy (called PD-1 therapy), your cancer has since grown or stopped responding, and this treatment ended at least 4 weeks before joining the trial with any side effects mostly resolved.
• Your cancer has tested negative for the HPV virus (tested using a specific laboratory method).
• You can provide a tumor tissue sample (either a stored sample from within the last 2 years or a fresh sample) for laboratory testing.
• You are generally active and able to carry out daily activities with little or no restriction (confirm with trial site regarding the specific fitness scale used).
• Your doctor expects you to live for at least 12 weeks.
• Your blood counts, liver, kidneys, urine, blood sugar, lung function, and heart are all working well enough based on blood and other tests taken within 2 weeks before starting treatment (confirm with trial site for specific values).

Who may not be able to join:

• You have previously been treated with cetuximab or similar drugs that target a protein called EGFR (either as an injection or a pill).
• You are currently receiving any cancer treatment.
• You have taken part in another clinical trial within the 4 weeks before starting this study.
• You have received certain blood-boosting injections (such as G-CSF or erythropoietin) within 1 week before starting the study.
• You have tested positive for HIV or syphilis.
• You have active hepatitis B or hepatitis C, confirmed by specific blood tests.
• You have a known allergy or sensitivity to the type of drug being used in this trial or its ingredients.
• You have a large build-up of fluid in your lungs or abdomen that is causing symptoms and needs treatment.
• You have an active lung condition such as interstitial lung disease, pneumonia, asthma, or obstructive lung disease, or a history of active tuberculosis.
• You have any serious uncontrolled health problem, including severe infection, poorly controlled diabetes, significant heart problems, blood clots, recent stroke or heart attack, or certain heart procedures within the last 6 months (confirm with trial site for the full list).
• You have previously had a stem cell transplant or organ transplant.
• You have a history of drug or substance misuse that you are unable to stop, or a history of serious psychiatric illness.
• You have had another type of cancer within the past 5 years.
• Your doctor believes you are unlikely to follow the trial requirements or that participation would not be appropriate for another reason.
• You have other serious medical conditions or abnormal test results that the trial doctor believes could put you at risk or affect the trial results (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.