Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to take part voluntarily, have been fully informed about the study, and are able to sign a consent form and follow all study procedures.
• People aged 18 or older (any gender).
• People who have been formally diagnosed with glioblastoma (GBM) through a tissue test.
• People who have had partial surgical removal of the tumour, or whose tumour has come back or grown, between 2 and 6 weeks after surgery and before radiation treatment has started.
• People whose blood, liver, kidney, and clotting function results meet specific minimum levels set by the trial (confirm with trial site for exact values).
• People whose heart pumping function (measured as left ventricular ejection fraction) is at least 50%.
• Women of childbearing potential whose pregnancy test is negative and who agree to use effective contraception from the time of signing the consent form until 6 months after the last chemotherapy dose.
• People whose thyroid hormone levels (TSH, FT4, and FT3) are within 10% of the normal range.
• People who are able to have a full eye examination including a dilated fundus check, slit lamp examination, and colour photographs of the back of the eye.

Who may not be able to join:

• People currently taking part in another clinical trial, or who finished treatment in a previous clinical trial less than 4 weeks ago.
• People who have had another cancer (other than GBM) in the past 3 years, or who have another active primary cancer that has not been cured.
• People who have previously had radiation therapy to the brain.
• People who are pregnant or breastfeeding.
• People who, after medical assessment, are found to have a medical reason they cannot safely receive radiation therapy.
• People with serious active health conditions that could interfere with the treatments used in this study.
• People with an active infection (bacterial, fungal, viral, or other) that requires treatment with antibiotics or other anti-infective medicines.
• People who, within the 6 months before joining the trial, have been diagnosed with heart failure, unstable chest pain (angina), serious uncontrolled heart rhythm problems, acute reduced blood flow to the heart, or a heart attack.
• People with a specific heart rhythm measurement (QTcF interval) greater than 480 milliseconds, unless this is caused by a bundle branch block (confirm with trial site).
• People with uncontrolled health conditions including, but not limited to, uncontrolled high blood pressure, active stomach ulcers, or bleeding disorders.
• People with a history of mental illness, or people who do not have full legal capacity to make decisions.
• People with any other medical history, condition, or abnormal test result that the trial doctors consider may interfere with the study or make participation unsuitable.

Important: Always verify eligibility with the trial site directly before applying.