Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to sign a consent form and follow the study rules
• Adults aged 18 to 75 years old
• People diagnosed with stage II to IIIB non-small cell lung cancer (a specific type of lung cancer) that has a particular genetic change called an EGFR-sensitive mutation, where surgery to remove the affected lung lobe is considered possible or potentially possible, and the doctor has determined that treatment before surgery is needed
• People whose lungs are working well enough to handle surgery
• People who have at least one tumour that can be measured on scans, according to standard research guidelines
• People who are generally well enough to carry out daily activities with little or no limitation (as assessed by a standard medical scale)
• People with no serious heart problems, and whose heart is pumping at a healthy level (at least 50% efficiency)
• People whose bone marrow, liver, and kidney function all meet specific blood test thresholds set by the trial (confirm with trial site for exact values)
• People whose blood-clotting function falls within the acceptable range set by the trial
• People with a low level of protein in their urine, within the limits set by the trial
• People of childbearing potential who agree to use highly effective contraception from 7 days before the first dose until 6 months after the last dose; women of childbearing potential must also have a negative pregnancy blood test within 7 days before starting treatment

Who may not be able to join:

• People who have already received any previous treatment (systemic or local) for non-small cell lung cancer
• People who have had another type of cancer within the past 5 years, unless it was a fully cured skin cancer, superficial bladder cancer, or certain in situ cancers (such as prostate, cervical, or breast — confirm with trial site)
• People who have had a major surgical procedure within 4 weeks before starting the trial
• People who currently have, or have a history of, certain types of lung inflammation (such as interstitial lung disease or radiation-related lung damage requiring steroid treatment)
• People who have had a serious infection within 4 weeks before the screening period, such as a severe bacterial, viral, or fungal infection
• People who have an active autoimmune disease or a history of certain autoimmune conditions (such as lupus, Crohn's disease, or Guillain-Barré syndrome); some exceptions apply, including stable thyroid conditions managed with hormone replacement and skin conditions not needing systemic treatment (confirm with trial site)
• People who test positive for HIV, have active tuberculosis, or have an active hepatitis B or C infection
• People with poorly controlled high blood pressure (above certain thresholds set by the trial)
• People with a history of serious heart or brain blood vessel problems, including certain abnormal heart rhythms, heart failure, stroke, heart attack, or aortic dissection — particularly if these occurred within the past 6 months (confirm with trial site for full details)
• People who have previously received a stem cell, bone marrow, or organ transplant from another person
• People with a known allergy to the study drugs or any of their ingredients
• People who have previously had any type of stem cell transplant (from themselves or another person)
• Women who are pregnant or breastfeeding
• People the trial doctor considers unsuitable for the trial for any other reason

Important: Always verify eligibility with the trial site directly before applying.