Phase 3 Long COVID Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older, of any sex
• You are able to sign and date a consent form agreeing to take part
• You are able to attend all study visits in person at 5 East 98th St, New York, NY
• You have been formally diagnosed with Long COVID by a doctor
• You had a confirmed or suspected COVID-19 infection at least 6 months before contacting the study team
• You have had at least one of the following symptoms for at least 6 months after your COVID-19 infection: headache, memory problems, insomnia, mood changes, chest pain, heart palpitations, shortness of breath, cough, muscle pain, joint pain, or stomach/digestive problems
• You experience at least moderate fatigue, as measured by a specific fatigue questionnaire
• You experience at least moderate post-exertional malaise (worsening of symptoms after physical or mental effort), as measured by a specific screening tool
• Your quality of health score was 80 or above before your COVID-19 infection, and is now 70 or below (measured by a survey before the study begins)
• You are willing and able to follow all study procedures, attend appointments, and complete all required tests and surveys

Who may not be able to join:

• You have a pre-existing autoimmune condition (such as chronic Epstein-Barr virus, Multiple Sclerosis, or Hashimoto's Disease) that could affect immune testing results
• You were diagnosed before 2020 with another post-infectious illness, such as Chronic Lyme Disease or Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
• You have a documented history of a vaccine injury
• You have had a lung or liver transplant
• You have known liver or kidney problems
• You weigh less than 40 kg (approximately 88 lbs)
• You have any other long-term condition that could affect immune test results, as judged by the study doctor
• You are currently taking a medication called sirolimus
• You are currently taking certain medications that are known to interact with sirolimus — including some antibiotics, antifungals, heart medications, anti-seizure drugs, steroids, HIV medications, St. John's Wort, and grapefruit (confirm with trial site for the full list)
• You are currently taking ACE inhibitors (a type of blood pressure medication)
• You have had a fever or illness with fever within the last 3 months before your baseline study visit
• You have taken part in another clinical trial or received an experimental treatment within the last 3 months before your baseline study visit
• You have uncontrolled diabetes, unstable heart disease, significant lung disease, a history of immune deficiency, are receiving immune-suppressing treatment, have a blood clotting disorder or take long-term blood thinners, or have liver problems
• You are pregnant or planning to become pregnant
• You are currently breastfeeding

Important: Always verify eligibility with the trial site directly before applying.