Phase 2 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to take part and have signed a consent form agreeing to participate
• You are between 18 and 75 years old (male or female)
• Your doctors expect you to live for at least 3 more months
• You are generally active and able to care for yourself, with little or no limitation in daily activities (confirm with trial site)
• You have been diagnosed with kidney cancer that has spread locally or to other parts of the body, confirmed by a tissue or cell test
• You are willing to provide a stored or fresh tumor tissue sample taken within the last 3 years
• You have at least one area of cancer that can be measured on a scan, according to standard criteria
• Your organs (such as kidneys, liver, and heart) are functioning well enough to meet the study's requirements (confirm with trial site)
• Any side effects from previous cancer treatments have mostly resolved or are very mild
• If you are able to have children, you must be willing to use highly effective birth control during the study and for 7 months after your first dose, and women must have a negative pregnancy test within 7 days before starting

Who may not be able to join:

• You have had chemotherapy, biological therapy, or other cancer treatments within the past 4 weeks (or within 5 half-lives of the drug), or certain specific chemotherapy drugs within the past 6 weeks
• You have previously been treated with a type of targeted drug (called an ADC) that uses a camptothecin-based substance
• You have taken immune-modifying drugs within 14 days before starting the trial
• You have had a serious heart or stroke-related condition in the past 6 months
• You have certain heart rhythm problems, including a prolonged QT interval, complete left bundle branch block, third-degree heart block, or uncontrolled irregular heartbeat
• You currently have an active autoimmune or inflammatory disease
• You need to take steroid or immune-suppressing medications within 2 weeks before starting the trial
• You have had another type of cancer within the past 5 years
• You have a history of lung inflammation (ILD) that required steroid treatment, or currently have or are suspected to have lung inflammation
• You have poorly controlled diabetes or serious diabetes-related complications
• You have had an unstable blood clot requiring treatment within the past 6 months
• You have a serious lung disease that significantly affects your breathing
• Your cancer has actively spread to your brain or spinal cord
• You have large or symptomatic fluid build-up in the body that is not well controlled
• You have a known allergy to the study drugs or any of their ingredients
• You have previously had a stem cell, bone marrow, or organ transplant from another person
• You are HIV-positive, or have active tuberculosis, active hepatitis B, or active hepatitis C
• You had a serious infection within 4 weeks before starting, or have a lung infection currently
• You have taken part in another clinical trial within the past 4 weeks
• You have a history of serious mental illness or substance abuse that you are unable to stop
• Scans show the tumor has grown into or around major blood vessels in the chest
• You have a serious wound, ulcer, or broken bone that has not healed within the past 4 weeks
• You have had significant bleeding or a strong tendency to bleed within the past 4 weeks
• You have received or are planning to receive a live vaccine within 28 days before starting the trial
• You have other serious health problems or test results that the trial doctors feel would make participation unsafe or affect the study results

Important: Always verify eligibility with the trial site directly before applying.