Phase 2 Melanoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older
• You are reasonably active and able to care for yourself with little or no help with daily activities (confirm with trial site)
• You have been diagnosed with skin or acral (hands/feet) melanoma that has been confirmed by a tissue or cell sample — mucosal (inside body) and eye melanomas do not qualify
• You have been tested for specific gene changes (BRAF, CKIT, and NRAS)
• You have not received any cancer treatment before for this condition
• Your melanoma is at clinical Stage II (based on a specific staging system from 2017)
• Your blood counts, liver, kidney, and clotting results are within acceptable ranges (confirmed through recent lab tests)
• Your heart is pumping blood effectively enough (at least 50% efficiency, confirmed by ultrasound)
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 7 days before joining, not be breastfeeding, and agree to use contraception during the study and for 6 months after
• If you are a man, you must agree to use contraception during the study and for 6 months after
• You are willing to take part, sign a consent form, and follow the study's requirements

Who may not be able to join:

• You have had an allergic reaction to biological medicines in the past
• You have had another cancer in the past 5 years (exceptions may apply for certain fully cured skin cancers or cervical pre-cancers — confirm with trial site)
• You have an active autoimmune disease or a history of certain autoimmune conditions (such as autoimmune liver disease, lung inflammation, bowel inflammation, or asthma needing regular medication — some milder conditions like vitiligo or controlled thyroid problems may be exceptions)
• You have taken strong immune-suppressing steroids (equivalent to more than 10mg of prednisone per day) in the 2 weeks before starting the trial
• You have a history of significant bleeding problems, had a serious bleeding episode in the last 4 weeks, or have unhealed wounds, broken bones, active stomach ulcers, or other conditions that could cause bleeding or bowel perforation
• You have poorly controlled high blood pressure (top number 150 or above, or bottom number 90 or above)
• You have had unstable chest pain, a heart attack, significant heart failure, or a heart rhythm problem requiring treatment in the past 6 months
• You have an active or poorly controlled serious infection
• You have active hepatitis B or C with detectable virus levels in your blood, advanced liver disease, or HIV
• You have poorly controlled diabetes
• You have significant protein in your urine (confirm with trial site)
• You have received a live vaccine in the 4 weeks before treatment or expect to need one during the study
• You have other serious health conditions, mental health conditions, or personal circumstances that the study doctors believe could affect your safety or the study results

Important: Always verify eligibility with the trial site directly before applying.